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首页> 外文期刊>European Journal of Pharmacology: An International Journal >Reduction of myocardial infarct size by SM-197378, a novel Na(+)/H(+) exchange inhibitor, in rabbits.
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Reduction of myocardial infarct size by SM-197378, a novel Na(+)/H(+) exchange inhibitor, in rabbits.

机译：SM-197378，一种新型的Na（+）/ H（+）交换抑制剂，可减少兔的心肌梗塞面积。

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摘要

The effects of SM-197378, 2-[[[amino(imino)methyl]amino]carbonyl]-1-methyl-4-trifluoromethyl-1H-indo l-7-yl=hydrogen=sulfate monohydrate, a novel potent Na(+)/H(+)exchange inhibitor, on heart injury were studied using a rabbit model involving 30 min of myocardial ischemia and 5 h of reperfusion. Intravenous administration of SM-197378 before ischemia reduced the infarct size by approximately 30-50% in a dose-dependent manner. This anti-necrotic effect was achieved without significant hemodynamic changes. Moreover, administration of SM-197378 before reperfusion also resulted in a significant, approximately 30-40%, reduction in the infarct size. The anti-necrotic effect of pre-ischemic bolus treatment with SM-197378 was compared with that of nicorandil, a K(+)channel opener with nitrate-like activity, and ischemic preconditioning. With 30 and 60 min of ischemia, the anti-necrotic effects of SM-197378 and ischemic preconditioning were similar and superior to that of nicorandil. With 90 min of ischemia, the anti-necrotic effect of SM-197378 was superior to that of ischemic preconditioning.
机译：SM-197378，2-[[[[（（氨基（亚氨基）甲基]氨基]羰基] -1-甲基-4-三氟甲基-1H-吲哚-1-7-基=氢=硫酸盐一水合物）的作用使用涉及30分钟心肌缺血和5小时再灌注的兔子模型研究了+）/ H（+）交换抑制剂对心脏的伤害。缺血前静脉给药SM-197378以剂量依赖性方式将梗塞面积减少了约30-50％。在没有明显的血液动力学变化的情况下实现了这种抗坏死作用。此外，在再灌注前施用SM-197378还可以显着减少梗塞面积约30-40％。比较了使用SM-197378进行缺血前大剂量治疗的抗坏死作用与具有硝酸盐样活性的K（+）通道开放剂尼可地尔和缺血预处理的抗坏死作用。在缺血30和60分钟时，SM-197378和缺血预处理的抗坏死作用相似且优于尼可地尔。在缺血90分钟后，SM-197378的抗坏死作用优于缺血预处理。

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