Application of a physiologically based pharmacokinetic model for the evaluation of single-point plasma phenotyping method of CYP2D6

Chen Rui; Rostami-Hodjegan Amin; Wang Haotian; Berk David; Shi Jun; Hu Pei

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Application of a physiologically based pharmacokinetic model for the evaluation of single-point plasma phenotyping method of CYP2D6

机译：基于生理学的药代动力学模型在CYP2D6单点血浆表型评价方法中的应用

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Purpose: Determining metabolic ratio from single-point plasma is potentially a good phenotyping method of CYP2D6 to reduce the required time interval and increase the reliability of data. It is difficult to conduct large sample size clinical trials to evaluate this phenotyping method for multiple plasma points. A physiologically based pharmacokinetic (PBPK) model can be developed to do simulations based on the large virtual Chinese population and evaluate single-point plasma phenotyping method of CYP2D6.

机译：目的：从单点血浆确定代谢率可能是CYP2D6的一种好的表型分析方法，以减少所需的时间间隔并增加数据的可靠性。很难进行大样本的临床试验来评估针对多个血浆点的这种表型分析方法。可以开发基于生理的药代动力学（PBPK）模型，以基于大量的中国虚拟人群进行模拟，并评估CYP2D6的单点血浆表型分析方法。

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来源
《European journal of pharmaceutical sciences》 |2016年第null期|共6页
作者
Chen Rui; Rostami-Hodjegan Amin; Wang Haotian; Berk David; Shi Jun; Hu Pei;
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正文语种 eng
中图分类药学;
关键词
CYP2D6; Phenotyping method; Physiologically based pharmacoldnetic model; Virtual population;

机译：CYP2D6;表型分析方法;基于生理学的药理学模型;虚拟人群;

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1. Application of a physiologically based pharmacokinetic model for the evaluation of single-point plasma phenotyping method of CYP2D6 [J] . Chen Rui, Rostami-Hodjegan Amin, Wang Haotian, European journal of pharmaceutical sciences . 2016,第Null期

机译：基于生理学的药代动力学模型在CYP2D6单点血浆表型评价方法中的应用
2. Physiologically Based Pharmacokinetic Modeling to Evaluate the Systemic Exposure of Gefitinib in CYP2D6 CYP2D6 Ultrarapid Metabolizers and Extensive Metabolizers [J] . Chen Yingxue, Zhou Diansong, Tang Weifeng, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2018,第4期

机译：基于生理学的药代动力学建模，以评估CYP2D6 CYP2D6 Ultrapid代谢物和广泛代谢的Gefitinib的全身暴露
3. Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights [J] . Priyanka Arora, Gary Gudelsky, Pankaj B. Desai PLoS One . 2021,第4期

机译：Sprague-Dawley大鼠Letrozole脑和血浆药代动力学的基于性别的差异：应用基于生理学的药代动力学建模以获得定量见解
4. Self-Regulating Physiologically Based Pharmacokinetic Model and Creation of Drug Concentration Profiles in Plasma and Tissues [C] . Stanislav Polinkevych International Conference on Bioinformatics Computational Biology . 2011

机译：基于生理的药代动力学模型和血浆和组织中药物浓度谱的创造
5. Applications of Physiologically Based Pharmacokinetic Modelling to Prediction of the Likelihood of Metabolic Drug Interactions in Paediatric Population and Studying Disparities in Pharmacokinetics Between Children and Adults [D] . Salem, Farzaneh. 2014

机译：基于生理的药代动力学模型在小儿人群中代谢药物相互作用的可能性预测和研究儿童与成人之间药代动力学差异的应用
6. Modelling Age-Related Changes in the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone in Different CYP2D6 Phenotypes Using a Physiologically Based Pharmacokinetic Approach [O] . Lisa Alina Kneller, Georg Hempel -1

机译：使用基于生理的药代动力学方法对不同CYP2D6表型的利培酮和9-羟基利培酮的药代动力学与年龄相关的变化进行建模
7. Application of a physiologically based pharmacokinetic model for the evaluation of single-point plasma phenotyping method of CYP2D6 [O] . Chen, Rui, Rostami-Hodjegan, Amin, Wang, Haotian, 2016

机译：应用生理学药代动力学模型评估CYp2D6单点血浆表型分析方法

Application of a physiologically based pharmacokinetic model for the evaluation of single-point plasma phenotyping method of CYP2D6

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