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首页> 外文期刊>European journal of epidemiology >Three-year (1999-2002) of epidemiological and virological surveillance of influenza in north-east Italy.
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Three-year (1999-2002) of epidemiological and virological surveillance of influenza in north-east Italy.

机译：在意大利东北部，对流行性感冒进行流行病学和病毒学监测的三年（1999年至2002年）。

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摘要

The results of the epidemiological and virological surveillance of influenza performed during the 1999/2000, 2000/2001 and 2001/2002 seasons in the northeastern Italy were presented and the relationship between age-specific morbidity rates and circulating strains were discussed.The epidemiological findings pointed out a change in age distribution. During the 1999/2000 season, characterized by a circulation of viruses antigenically close to the vaccine strain, a similar incidence rate in the 0-14 and 15-64-year-old groups was observed, while during the 2001/ 2002 winter the virus infected mostly children. During 2001/2002 season, B type viruses predominated with at least three distinguishable molecular variants. In particular, B/Victoria/2/87-like viruses re-emerged after more than a decade, and the antibodies elicited by the vaccine strain and by the strains circulating in previous seasons were poor or not protecting. The accumulation of susceptible subjects in young age group during the 1990s, due to the lack of circulation of B/Victoria/2/87-like viruses, was responsible for the unusual morbidity in the 0-14 year group. No circulation of B/Victoria/2/87-like viruses was observed in > 64-year-old group during 2001/2002 epidemic, probably due to a long-lasting immunity against viruses belonging to this lineage.
机译：介绍了在意大利东北部1999 / 2000、2000 / 2001和2001/2002季节进行的流感流行病学和病毒学监测结果，并讨论了特定年龄段发病率与循环株之间的关系。改变年龄分布。在1999/2000季节，以抗原在疫苗株附近的抗原传播为特征，在0-14岁和15-64岁组中观察到了相似的发病率，而在2001/2002年冬季，该病毒发生了感染多为儿童。在2001/2002赛季中，B型病毒以至少三种可区分的分子变体为主导。特别地，十多年来，B / Victoria / 2/87样病毒再次出现，并且由疫苗株和先前季节中流通的株引起的抗体很差或没有保护性。在1990年代，由于缺乏B / Victoria / 2/87样病毒的传播，易感人群在年轻人群中的积累是造成0-14岁人群异常发病的原因。在2001/2002年流行期间，在64岁以上的人群中未观察到B / Victoria / 2/87样病毒的传播，这可能是由于针对该血统的病毒具有长期免疫力。

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