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首页> 外文期刊>European journal of pharmaceutical sciences >Non-ablative fractional laser assists cutaneous delivery of small- and macro-molecules with minimal bacterial infection risk
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Non-ablative fractional laser assists cutaneous delivery of small- and macro-molecules with minimal bacterial infection risk

机译：非烧蚀性分级激光可帮助小分子和大分子通过皮肤输送，将细菌感染的风险降至最低

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Use of the ablative laser has been approved to enhance topical drug penetration. Investigation into the usefulness of the non-ablative laser for assisting drug delivery is very limited. In this study, we explored the safety and efficacy of the non-ablative fractional erbium:glass (Er:glass) laser as an enhancement approach to promote drug permeation. Both pig and nude mouse skins were employed as transport barriers. We histologically examined the skin structure after laser exposure. The permeants of 5-aminolevulinic acid (ALA), imiquimod, tretinoin, peptide, dextrans and quantum dots (QD) were used to evaluate in vitro and in vivo skin passage. The fractional laser selectively created an array of photothermal dots deep into the dermis with the preservation of the stratum corneum and epidermis. The barrier function of the skin could be recovered 8-60 h post-irradiation depending on the laser spot densities. The application of the laser caused no local infection of Staphylococcus aureus and Pseudomonas aeruginosa. Compared to intact skin, ALA flux was enhanced up to 1200-fold after laser exposure. The penetration enhancement level by the laser was decreased following the increase of permeant lipophilicity. The skin accumulation of tretinoin, an extremely lipophilic drug, showed only a 2-fold elevation by laser irradiation. The laser promoted peptide penetration 10-fold compared to the control skin. Skin delivery of dextrans with a molecular weight (MW) of at least 40 kDa could be achieved with the Er:glass laser. QD with a diameter of 20 nm penetrated into the skin with the assistance of the non-ablative laser. The confocal microscopic images indicated the perpendicular and lateral diffusions of dextrans and nanoparticles via laser-created microscopic thermal zones. Controlled Er:glass laser irradiation offers a valid enhancement strategy to topically administer the permeants with a wide MW and lipophilicity range. (C) 2016 Elsevier B.V. All rights reserved.
机译：已经批准使用消融激光来增强局部药物渗透。非消融激光用于辅助药物递送的用途的研究非常有限。在这项研究中，我们探讨了非烧蚀性分数:：玻璃（Er：玻璃）激光作为促进药物渗透的增强方法的安全性和有效性。猪皮和裸鼠皮都被用作运输屏障。我们通过组织学检查了激光照射后的皮肤结构。 5-氨基乙酰丙酸（ALA），咪喹莫特，维甲酸，肽，葡聚糖和量子点（QD）的渗透物用于评估体内和体外皮肤通过。分数激光选择性地在真皮深处产生了一系列光热点，并保留了角质层和表皮。皮肤的屏障功能可以在照射后8-60小时恢复，具体取决于激光点的密度。激光的应用未引起金黄色葡萄球菌和铜绿假单胞菌的局部感染。与完整的皮肤相比，激光照射后ALA的通量提高了1200倍。随着渗透亲脂性的增加，激光的渗透增强水平降低。维甲酸（一种高度亲脂性药物）在皮肤上的积累通过激光照射仅能显示2倍的升高。与对照皮肤相比，激光可促进肽穿透10倍。分子量（MW）至少为40 kDa的右旋糖酐可以通过Er：glass激光进行皮肤输送。直径为20 nm的QD在非烧蚀激光的帮助下渗透到皮肤中。共聚焦显微镜图像表明右旋糖酐和纳米颗粒通过激光产生的微观热区的垂直和横向扩散。受控的Er：玻璃激光辐照提供了有效的增强策略，可局部施用分子量和亲脂性较宽的渗透剂。 （C）2016 Elsevier B.V.保留所有权利。

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