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首页> 外文期刊>European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V >A comparison between povidone-ethylcellulose and povidone-eudragit transdermal dexamethasone matrix patches based on in vitro skin permeation.
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A comparison between povidone-ethylcellulose and povidone-eudragit transdermal dexamethasone matrix patches based on in vitro skin permeation.

机译：基于体外皮肤渗透的聚乙烯吡咯烷酮-乙基纤维素和聚乙烯吡咯烷酮-eudragit透皮地塞米松基质贴剂之间的比较。

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摘要

The present study was designed to develop a suitable matrix type transdermal drug delivery system (TDDS) of dexamethasone using blends of two different polymeric combinations, povidone (PVP) and ethylcellulose (EC) and Eudragit with PVP. Physical studies including moisture content, moisture uptake, flatness to study the stability of the formulations and in vitro dissolution of the experimental formulations were performed to determine the amount of dexamethasone present in the patches were performed and scanning electron microscopy (SEM) photographs of the prepared TDDS were taken to see the drug distribution pattern. Drug-excipient interaction studies were carried out using Fourier transform infrared (FTIR) spectroscopic technique. In vitro skin permeation study was conducted in a modified Franz's diffusion cell. All the formulations were found to be suitable for formulating in terms of physicochemical characteristics and there was no significant interaction noticed between the drug and polymers used. In vitro dissolution studies showed that the drug distribution in the matrix was homogeneous and the SEM photographs further demonstrated this. The formulations of PVP:EC provided slower and more sustained release of drug than the PVP:Eudragit formulations during skin permeation studies and the formulation PVP:EC (1:5) was found to provide the slowest release of drug. Based on the above observations, it can be reasonably concluded that PVP-EC polymers are better suited than PVP-Eudragit polymers for the development of TDDS of dexamethasone.
机译：本研究旨在使用两种不同的聚合物组合（聚维酮（PVP）和乙基纤维素（EC）以及Eudragit与PVP）的混合物，开发一种适合的地塞米松基质型透皮给药系统（TDDS）。进行包括水分含量，水分吸收，平坦度的物理研究以研究制剂的稳定性以及在体外溶解实验制剂，以确定存在于贴剂中的地塞米松的量，并对其制备的扫描电子显微镜（SEM）照片用TDDS观察药物分布模式。使用傅里叶变换红外（FTIR）光谱技术进行了药物-赋形剂相互作用的研究。在改良的Franz扩散池中进行了体外皮肤渗透研究。发现所有制剂在理化特性方面均适合于配制，并且药物与所用聚合物之间没有发现明显的相互作用。体外溶出研究表明，药物在基质中的分布是均匀的，SEM照片进一步证明了这一点。在皮肤渗透研究期间，PVP：EC制剂比PVP：Eudragit制剂提供的药物释放更缓慢和更持久，并且发现PVP：EC（1：5）制剂提供的药物释放最慢。基于上述观察，可以合理地得出结论，对于地塞米松TDDS的开发，PVP-EC聚合物比PVP-Eudragit聚合物更适合。

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