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首页> 外文期刊>European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V >Application of percolation model to the tensile strength and the reduced modulus of elasticity of three compacted pharmaceutical excipients.
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Application of percolation model to the tensile strength and the reduced modulus of elasticity of three compacted pharmaceutical excipients.

机译：渗流模型在三种压缩药物赋形剂的拉伸强度和降低的弹性模量中的应用。

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摘要

Percolation theory has been applied to several mechanical properties of pharmaceutical tablets. This power law describes the change of tablet's properties with the relative density. It defines critical tablet densities from which the mechanical properties start to change. The exponent in the law is expected to be universal for a mechanical property and numerical values are proposed in the literature. In this work, the percolation model was applied to the tensile strength and the reduced modulus of elasticity (obtained from surface indentation test) of three compacted pharmaceutical excipients (a microcrystalline cellulose, a lactose and an anhydrous calcium phosphate). Two approaches were proposed. First, the exponent was kept constant and equal to the values used in the literature (2.7 for the tensile strength and 3.9 for the reduced modulus of elasticity). Secondly, the critical tablet density (i.e. the percolation threshold) and the exponent were determined from the model. In the first approach, thepercolation thresholds were higher than the relative tapped density. Using the second approach, the experimentally determined exponents were not close to the values of the literature and the critical relative densities were higher than the relative tapped density or equal to zero. Then, this study showed that the exponent seems not universal and that the model must be used carefully.
机译：渗流理论已应用于药物片剂的几种机械性能。该幂定律描述了片剂特性随相对密度的变化。它定义了关键的片剂密度，机械性能由此开始改变。预期该规律的指数对于机械性能是通用的，并且在文献中提出了数值。在这项工作中，将渗滤模型应用于三种压实药物赋形剂（微晶纤维素，乳糖和无水磷酸钙）的拉伸强度和降低的弹性模量（从表面压痕测试中获得）。提出了两种方法。首先，指数保持恒定并等于文献中使用的值（拉伸强度为2.7，降低的弹性模量为3.9）。其次，从模型中确定片剂的临界密度（即渗透阈值）和指数。在第一种方法中，渗透阈值高于相对分接密度。使用第二种方法，实验确定的指数不接近文献的值，临界相对密度高于相对抽头密度或等于零。然后，这项研究表明该指数似乎不是通用的，必须谨慎使用该模型。

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