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首页> 外文期刊>European Journal of Pharmacology: An International Journal >Effects of nimodipine and pentoxyfylline in prevention of hepatic ischemic damage in rats at normal and hypothermic conditions.
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Effects of nimodipine and pentoxyfylline in prevention of hepatic ischemic damage in rats at normal and hypothermic conditions.

机译：尼莫地平和戊氧茶碱预防正常和低温条件下大鼠肝脏缺血性损伤的作用。

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摘要

Hepatic ischemia should be considered in serious liver injury, liver tumor resection and liver transplantation. There are other conditions that decrease hepatic blood flow and cause hepatic ischemia, such as hemorrhagic shock, sepsis, hepatic artery ligation, trauma, and certain vascular lesions. In this study, effects of nimodipine (a calcium channel blocker) and pentoxyfylline (a derivative of methylxanthine) on duration and degree of hepatic ischemia in rats at normothermic and hypothermic conditions are investigated. This study was performed on 6 groups of Wistar Albino type rats, each group consisting of 7 rats. Groups were separated into normothermic (A) and hypothermic (B) conditions AI-Control group, AII-Nimodipine group and AIII-Pentoxyfylline group, B IV-Control group, BV-Nimodipine group and BVI-Pentoxyfylline group respectively. After hepatic pedicle occlusion lasting 45 min, blood samples were drawn from the rats for evaluation of alanine aminotransferase (ALT), aspartate transaminase (AST) and lactate dehydrogenase (LDH) values. Moreover, hepatic biopsies were taken to assess pathological changes under electron microscopy. These changes were evaluated through a grading system. As a resu it has been shown that both nimodipine and pentoxyfylline delayed effects of hepatic ischemia in a statistically significant manner in comparison with the control group and these effects were found to be more significant in hypothermic conditions.
机译：严重肝脏损伤，肝肿瘤切除和肝移植时应考虑肝缺血。还有其他条件会减少肝血流量并引起肝缺血，例如失血性休克，败血症，肝动脉结扎，创伤和某些血管病变。在这项研究中，研究了常温和低温条件下尼莫地平（钙通道阻滞剂）和戊氧茶碱（甲基黄嘌呤的衍生物）对大鼠肝脏缺血持续时间和程度的影响。这项研究是对6组Wistar白化病大鼠进行的，每组由7只大鼠组成。将组分为常温（A）和低温（B）条件，AI对照组，AII-尼莫地平组和AIII-戊氧茶碱组，B IV-对照组，BV-尼莫地平组和BVI-戊氧茶碱组。肝蒂蒂闭塞持续45分钟后，从大鼠抽取血液样本以评估丙氨酸转氨酶（ALT），天冬氨酸转氨酶（AST）和乳酸脱氢酶（LDH）值。此外，在电子显微镜下进行肝活检以评估病理变化。这些变化是通过分级系统进行评估的。结果是;已经显示尼莫地平和戊氧茶碱与对照组相比以统计学上显着的方式延迟了肝缺血的作用，并且发现这些作用在低温条件下更显着。

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