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首页> 外文期刊>European Journal of Pharmacology: An International Journal >Differential effects of selective adenosine A1 and A2A receptor agonists on dopamine receptor agonist-induced behavioural responses in rats.
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Differential effects of selective adenosine A1 and A2A receptor agonists on dopamine receptor agonist-induced behavioural responses in rats.

机译：选择性腺苷A1和A2A受体激动剂对多巴胺受体激动剂诱导的大鼠行为反应的差异作用。

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The effects of the systemic (i.p.) administration of the selective adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) and the selective adenosine A2A receptor agonist sodium 2-p-carboxyethyl)phenylamino-5'-N-carboxamidoadenosine (CGS 21680) on different dopamine receptor agonist-induced behaviours were studied in the male rat. CGS 21680 (1 micromol/kg), but not CPA, was found to counteract the stereotypies induced by the non-selective dopamine receptor agonist apomorphine (0.25 mg/kg s.c.). Low doses of CGS 21680 (0.1 micromol/kg) and high doses of CPA (3 micromol/kg) counteracted yawning induced by the dopamine D2 selective agonist quinpirole (0.05 mg/kg). On the other hand, low doses of CPA (0.3 micromol/kg) antagonized grooming induced by the selective dopamine D1 receptor-selective agonist SKF 38393 (10 mg/kg i.p.), while CGS 21680 was ineffective. These results are consistent with the proposed existence of a selective antagonistic modulation of dopamine D1 and D2 receptors by adenosine A1 and A2A receptors, respectively. The ability of CGS 21680 to counteract apomorphine-induced stereotypies is weaker compared to its previously reported antagonistic effect of amphetamine-induced motor activity. This supports the hypothesis that adenosine A2A receptor agonists may be potential antipsychotic drugs with a low potential for extrapyramidal side effects.
机译：全身性（ip）施用选择性腺苷A1受体激动剂N6-环戊基腺苷（CPA）和选择性腺苷A2A受体激动剂2-对-羧乙基）苯基氨基-5'-N-羧酰胺基腺苷（CGS 21680）在雄性大鼠中研究了多巴胺受体激动剂诱导的行为。发现CGS 21680（1微摩尔/千克）而非CPA抵消了由非选择性多巴胺受体激动剂阿扑吗啡（0.25 mg / kg s.c.）引起的刻板印象。低剂量的CGS 21680（0.1 micromol / kg）和高剂量的CPA（3 micromol / kg）抵消了多巴胺D2选择性激动剂喹吡罗（0.05 mg / kg）引起的打哈欠。另一方面，低剂量的CPA（0.3 micromol / kg）拮抗了选择性多巴胺D1受体选择性激动剂SKF 38393（10 mg / kg i.p.）引起的修饰，而CGS 21680无效。这些结果与提出的分别由腺苷A1和A2A受体选择性拮抗多巴胺D1和D2受体的存在相一致。与以前报道的苯丙胺诱导的运动活性的拮抗作用相比，CGS 21680对抗阿扑吗啡诱导的刻板印象的能力较弱。这支持以下假设：腺苷A2A受体激动剂可能是潜在的抗精神病药物，锥体外系副作用的可能性很低。

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