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首页> 外文期刊>European Journal of Pharmacology: An International Journal >Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.
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Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.

机译：自由基清除剂依达拉奉对急性胰腺炎相关性肺损伤的保护作用。

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摘要

Impaired lung function is the primary contributor to most deaths associated with severe acute pancreatitis. It is widely accepted that oxidative stress plays a central role in the pathogenesis of pancreatitis and associated complications. Therefore, in the present study, we investigated whether therapeutic treatment with the free radical scavenger edaravone could protect rats against acute pancreatitis and the associated lung injury. Acute pancreatitis was induced by infusion of 1ml/kg of sodium taurocholate (3% solution) into the biliopancreatic duct. Edaravone (8mg/kg) was administered 1h and 13h after inducing pancreatitis, the severity of pancreatic and pulmonary injuries was evaluated 24h after inducing pancreatitis. Edaravone treatment significantly reduced the elevated malondialdehyde levels in rat lungs after acute pancreatitis, suggesting an important role for free radicals in acute pancreatitis-associated lung injury. In addition, edaravone showed significant protective effects against neutrophil infiltration and tissue injury in both pancreas and lung, as demonstrated by serum amylase levels, myeloperoxidase activity and histopathological analysis. Edaravone treatment also attenuated the elevated mRNA levels of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor alpha (TNF-alpha) in rat lungs after acute pancreatitis. In conclusion, edaravone protects rats against acute pancreatitis-associated lung injury, probably through its antioxidant and anti-inflammatory effects. Thus, edaravone shows promise as a treatment for lung injury in patients with acute pancreatitis.
机译：肺功能受损是导致与严重急性胰腺炎相关的大多数死亡的主要原因。氧化应激在胰腺炎和相关并发症的发病机理中起着核心作用，这一点已被广泛接受。因此，在本研究中，我们调查了自由基清除剂依达拉奉的治疗方法是否可以保护大鼠免于急性胰腺炎和相关的肺损伤。通过向胆胰管中输注1ml / kg牛磺胆酸钠（3％溶液）诱发急性胰腺炎。在诱发胰腺炎后1h和13h给予依达拉奉（8mg / kg），在诱发胰腺炎后24h评估胰腺和肺损伤的严重程度。依达拉奉治疗可显着降低急性胰腺炎后大鼠肺中丙二醛水平升高，表明自由基在急性胰腺炎相关性肺损伤中具有重要作用。此外，依达拉奉显示出对胰腺和肺中性粒细胞浸润和组织损伤的显着保护作用，如血清淀粉酶水平，髓过氧化物酶活性和组织病理学分析所证实。依达拉奉治疗还减轻了急性胰腺炎后大鼠肺中促炎性细胞因子白介素（IL）-6和肿瘤坏死因子α（TNF-alpha）mRNA水平的升高。总之，依达拉奉可能通过抗氧化和抗炎作用保护大鼠免受急性胰腺炎相关的肺损伤。因此，依达拉奉具有治疗急性胰腺炎患者肺损伤的潜力。

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