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首页> 外文期刊>European review for medical and pharmacological sciences. >Development of psoriasis scalp with alopecia during treatment of Crohn's disease with infliximab and rapid response to both diseases to ustekinumab
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Development of psoriasis scalp with alopecia during treatment of Crohn's disease with infliximab and rapid response to both diseases to ustekinumab

机译：英夫利昔单抗治疗克罗恩病期间银屑病头皮伴脱发的发展以及对两种疾病对ustekinumab的快速反应

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摘要

Anti tumor necrosis factor antibodies are used to treat both psoriasis and inflammatory bowel disease. Several paradoxical cases of psoriatic skin lesions induced by tumor necrosis factor antagonist therapy have been described in IBD patients in the recent years. Ustekinumab, a fully human anti-interleukin-12/-23 monoclonal antibody, is the first drug of a new class of biologic therapy approved for the treatment of moderate to severe plaque psoriasis. Data on the efficacy of ustekinumab in patients with moderate-to-severe Crohn's disease, especially in patients previously treated with infliximab, have been recently published. We report about the effectiveness of ustekinumab in the treatment of both severe scalp psoriasis lesions with alopecia and active Crohn's disease.
机译：抗肿瘤坏死因子抗体用于治疗牛皮癣和炎性肠病。近年来，在IBD患者中已经描述了几种由肿瘤坏死因子拮抗剂治疗引起的牛皮癣皮肤损害的自相矛盾的病例。 Ustekinumab是一种完全的人类抗白介素12 / -23单克隆抗体，是经批准用于治疗中度至重度斑块状牛皮癣的新型生物疗法中的第一种药物。乌斯他单抗在中至重度克罗恩病患者中，特别是在先前用英夫利昔单抗治疗的患者中的功效数据最近已发表。我们报道了ustekinumab在治疗伴有脱发症的严重头皮银屑病和活动性克罗恩病中的有效性。

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