首页> 外文期刊>European urology >Combined Ultrasmall Superparamagnetic Particles of Iron Oxide-Enhanced and Diffusion-Weighted Magnetic Resonance Imaging Reliably Detect Pelvic Lymph Node Metastases in Normal-Sized Nodes of Bladder and Prostate Cancer Patients
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Combined Ultrasmall Superparamagnetic Particles of Iron Oxide-Enhanced and Diffusion-Weighted Magnetic Resonance Imaging Reliably Detect Pelvic Lymph Node Metastases in Normal-Sized Nodes of Bladder and Prostate Cancer Patients

机译:氧化铁增强和弥散加权磁共振成像的超小超顺磁粒子组合可可靠地检测膀胱和前列腺癌患者正常大小淋巴结中的盆腔淋巴结转移

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摘要

Background: Lymph node staging of bladder or prostate cancer using conventional imaging is limited. Newer approaches such as ultrasmall superparamagnetic particles of iron oxide (USPIO) and diffusion-weighted magnetic resonance imaging (DW-MRI) have inconsistent diagnostic accuracy and are difficult to interpret. Objective: To assess whether combined USPIO and DW-MRI (USPIO-DW-MRI) improves staging of normal-sized lymph nodes in bladder and/or prostate cancer patients.Design, setting, and participants: Twenty-one consecutive patients with bladder and/or prostate cancer were enrolled between May and October 2008. One patient was excluded secondary to bone metastases detected on DW-MRI with subsequent abstention from surgery.Intervention: Patients preoperatively underwent 3-T MRI before and after administration of lymphotropic USPIO using conventional MRI sequences combined with DW-MRI. Surgery consisted of extended pelvic lymphadenectomy and resection of primary tumors.
机译:背景:使用常规成像技术对膀胱或前列腺癌的淋巴结分期有限。诸如铁氧化物的超小超顺磁性颗粒(USPIO)和扩散加权磁共振成像(DW-MRI)之类的较新方法具有不一致的诊断准确性,并且难以解释。目的:评估USPIO和DW-MRI联合检查(USPIO-DW-MRI)是否能改善膀胱癌和/或前列腺癌患者正常大小的淋巴结分期。设计,背景和参与者:连续21例膀胱癌和/或前列腺癌患者/或在2008年5月至10月之间招募了前列腺癌。1例患者因DW-MRI检测出的骨转移继发,随后又因手术而放弃手术。序列与DW-MRI结合。手术包括扩大的盆腔淋巴结清扫术和切除原发性肿瘤。

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