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Hypothyroidism and Depression

机译：甲状腺功能减退和抑郁

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Background: A relationship between hypothyroidism and depression has been assumed for many years; however, the true nature of this association has been difficult to define with many conflicting studies. In recent years, our knowledge in this area has increased significantly with large cohort studies and genetically driven studies being published. Objectives: We reviewed the literature on thyroid function and depression to determine if this relationship has been clarified. Methods: We performed a search on the Pubmed database using the terms 'thyroid' and 'mental health', 'depression' and 'well-being'. Results: Large epidemiological studies generally suggest no association between thyroid function and depression in subjects without thyroid disease. Subjects on thyroxine have poorer psychological well-being than subjects with no thyroid disease even if biochemically euthyroid, they also show an association between thyroid function and well-being. Whilst there is some early evidence that genetic factors can influence well-being on thyroxine and response to combination therapy, there is also evidence to suggest that much morbidity on thyroxine may be due to initial misdiagnosis and mis-attribution of symptoms.
机译：背景：甲状腺功能减退症与抑郁症之间的关系已有多年的假设。但是，通过许多相互矛盾的研究很难确定这种关联的真实性质。近年来，随着大型队列研究和遗传驱动研究的发表，我们在这一领域的知识大大增加。目的：我们回顾了有关甲状腺功能和抑郁症的文献，以确定这种关系是否已经阐明。方法：我们在Pubmed数据库中使用“甲状腺”和“精神健康”，“抑郁”和“幸福”进行搜索。结果：大型流行病学研究通常表明，在没有甲状腺疾病的受试者中，甲状腺功能与抑郁之间没有关联。即使在生化方面甲状腺功能正常，服用甲状腺素的受试者的心理健康状况也比没有甲状腺疾病的受试者差，他们也表现出甲状腺功能与健康状况之间的关联。尽管有一些早期证据表明遗传因素会影响甲状腺素的健康和对联合疗法的反应，但也有证据表明甲状腺素的大量发病可能是由于最初的误诊和症状的错误归因所致。

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