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首页> 外文期刊>European thyroid journal >Iodine Supplementation throughout Pregnancy Does Not Prevent the Drop in FT4 in the Second and Third Trimesters in Women with Normal Initial Thyroid Function
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Iodine Supplementation throughout Pregnancy Does Not Prevent the Drop in FT4 in the Second and Third Trimesters in Women with Normal Initial Thyroid Function

机译：初始甲状腺功能正常的妇女在整个妊娠期间补充碘不能阻止FT4下降。

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Objectives: The aim of the study was to determine the evolution of thyroid tests throughout pregnancy and postpar-tum in healthy women with and without iodine supplementation. Methods: This was a prospective, randomized, inter-ventional study of iodine supplementation (150 ug/day) from the first trimester until 3 months postpartum versus controls. 111 pregnant women with normal initial thyroid tests were enrolled, undergoing comprehensive thyroid assessment at each trimester. We present results of longitudinal and cross-sectional analyses. Results: Initial ioduria suggested mild iodine deficiency in both groups, while third-trimester ioduria rose to levels of iodine sufficiency in the iodine-supplemented group. In the longitudinal study, free T4 (FT4) levels decreased in the second and third trimesters compared to the first trimester in both groups, with no change in TSH, and rose postpartum, though lower than the first trimester. FT3 levels and the total T4 (TT4)/thyroxine-binding globulin (TBG) ratio followed the same evolution as FT4. TT4 levels rose due to TBG increase.
机译：目的：本研究的目的是确定健康孕妇在补充和不补充碘的情况下，整个妊娠和胎后甲状腺测试的进展。方法：这是从妊娠前三个月至产后3个月与对照组相比，对碘补充量（150 ug /天）进行的前瞻性，随机，介入性研究。纳入111名初始甲状腺检查正常的孕妇，每个孕期接受全面的甲状腺评估。我们提出了纵向和横截面分析的结果。结果：最初的碘尿提示两组均存在轻度碘缺乏症，而补充碘的组中晚期妊娠的碘尿升高至碘充足水平。在纵向研究中，两组的中，晚期三个月的游离T4（FT4）水平均低于前三个月，TSH无变化，产后升高，尽管低于前三个月。 FT3水平和总T4（TT4）/甲状腺素结合球蛋白（TBG）的比率与FT4相同。由于TBG增加，TT4水平上升。

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