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首页> 外文期刊>European thyroid journal >A Placebo-Controlled, Blinded and Randomised Study on the Effects of Recombinant Human Thyrotropin on Quality of Life in the Treatment of Thyroid Cancer
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A Placebo-Controlled, Blinded and Randomised Study on the Effects of Recombinant Human Thyrotropin on Quality of Life in the Treatment of Thyroid Cancer

机译：甲状腺激素治疗中重组人甲状腺素对生活质量影响的安慰剂对照，盲法和随机研究

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Background: It is well known that thyroid hormone withdrawal (THW) in thyroid cancer patients can induce a decrease in quality of life (QOL). Recombinant human thyrotropin (rh-TSH) has been used to avoid this; however, no blinded studies have ever documented the effect. Objective: To compare QOL in patients with differentiated thyroid cancer (DTC) treated with either rh-TSH or liothyronine (L-T_3) THW for 10 days. Study Design: Double-blind, randomised crossover. Patients: Fifty-six patients with DTC treated by total thyroidectomy and indication for postsurgery radioiodine (Rl) ablation therapy. Intervention: Randomisation to either L-T_3 and rh-TSH prior to the first Rl course and following this to ingest placebo tablets and receive placebo injections before a second Rl uptake measurement 4-6 months later, or to receive placebo before the primary Rl ablation and active therapy 4-6 months later. Main Outcome Measures: QOL was measured by SF-36 and 2 visual analogue scale (VAS) scores at baseline and during Rl therapy or Rl uptake.
机译：背景：众所周知，甲状腺癌患者的甲状腺激素戒断（THW）会导致生活质量（QOL）下降。重组人促甲状腺激素（rh-TSH）已被用来避免这种情况。但是，还没有盲目的研究证明这种作用。目的：比较rh-TSH或碘甲状腺素（L-T_3）THW治疗10天的分化型甲状腺癌（DTC）患者的生活质量。研究设计：双盲，随机交叉。患者：通过全甲状腺切除术治疗的56例DTC患者以及手术后放射性碘（R1）消融治疗的指征。干预：在第一个R1疗程之前随机分配至L-T_3和rh-TSH，然后在4-6个月后的第二次R1摄取测量之前摄入安慰剂片剂并接受安慰剂注射，或者在主要R1消融之前接受安慰剂并在4-6个月后进行积极治疗。主要结果测量：在基线以及在R1治疗或R1摄取过程中，通过SF-36和2个视觉模拟量表（VAS）评分测量QOL。

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