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首页> 外文期刊>European Polymer Journal >Methods for the preparation of doxycycline-loaded phb micro- and nano-spheres
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Methods for the preparation of doxycycline-loaded phb micro- and nano-spheres

机译：强力霉素负载的phb微球和纳米球的制备方法

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Natural and synthetic biodegradable polymers have been investigated for controlled drug release. Poly(3-hydroxybutyrate) can be produced by bacteria and is remarkable for this application due to its excellent biocompatibility and biodegradability. The objective of this work was to study different drug-entrapment and emulsification methods for the obtaining of doxycycline-loaded PHB micro- and nano-spheres. The micro-ano-particles were prepared by polymer precipitation via dialysis, simple emulsion (O/W) or multiple emulsion (W_1/O/W_2) applying solvent evaporation in the last two cases. This was carried out either by ultrasonication, dripping and/or high speed stirring. Different processing conditions were varied in order to evaluate their influence on morphology, size, and drug entrapment capabilities. The highest drug loading was obtained by single emulsion with high speed stirring. In the case of multiple emulsion, the combination of ultrasound with high speed stirring resulted in the most elevate process yield and drug loading capability.
机译：已经研究了天然和合成的生物可降解聚合物对药物释放的控制。聚（3-羟基丁酸酯）可以由细菌产生，并且由于其优异的生物相容性和可生物降解性而在该应用中非常引人注目。这项工作的目的是研究获得载有多西环素的PHB微球和纳米球的不同药物包埋和乳化方法。在最后两种情况下，通过透析，简单乳液（O / W）或多重乳液（W_1 / O / W_2）的聚合物沉淀，通过溶剂沉淀法制备了微米/纳米颗粒。这可以通过超声处理，滴加和/或高速搅拌来进行。为了评估它们对形态，大小和药物截留能力的影响，对不同的处理条件进行了更改。在高速搅拌下通过单乳液获得最高的药物载量。在多乳化液的情况下，超声与高速搅拌相结合可最大程度地提高工艺收率和载药量。

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