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首页> 外文期刊>European Polymer Journal >Radiation synthesis of acrylic acid/polyethyleneimine interpenetrating polymer networks (IPNs) hydrogels and its application as a carrier of atorvastatin drug for controlling cholesterol
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Radiation synthesis of acrylic acid/polyethyleneimine interpenetrating polymer networks (IPNs) hydrogels and its application as a carrier of atorvastatin drug for controlling cholesterol

机译：丙烯酸/聚乙烯亚胺互穿聚合物网络（IPNs）水凝胶的辐射合成及其作为阿托伐他汀药物控制胆固醇的载体的应用

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摘要

Gamma irradiation was used to form interpenetrating polymer networks structure (IPNs) hydrogels based on different ratios of acrylic acid monomer (AAc) and polyethyleneimine (PEI). The property-behavior was characterized by IR spectroscopy, gel content, thermogravimetric analysis (TGA) and swelling in water at room temperature and different pH values. The AAc/PEI hydrogels were used as a carrier for atorvastatin drug, in which the uptake-release character was studied. The results showed that the gel content of AAc/PEI hydrogels decreased greatly with increasing the ratio of PEI in the initial feeding solution. The AAc/PEI hydrogels displayed pH-sensitive character. The drug uptake-release study indicated that AAc/PEI hydrogels possessed controlled release behavior and that the release process depends on pH. In this respect, the release of atorvastatin drug was significant in acidic medium.
机译：基于丙烯酸单体（AAc）和聚乙烯亚胺（PEI）的不同比例，使用γ辐射形成互穿的聚合物网络结构（IPNs）水凝胶。通过IR光谱，凝胶含量，热重分析（TGA）以及在室温和不同pH值下在水中的溶胀来表征该性能行为。 AAc / PEI水凝胶用作阿托伐他汀药物的载体，在其中研究了其吸收释放特性。结果表明，随着初始进料溶液中PEI的增加，AAc / PEI水凝胶的凝胶含量大大降低。 AAc / PEI水凝胶显示出pH敏感特性。药物吸收释放研究表明，AAc / PEI水凝胶具有控制释放行为，并且释放过程取决于pH值。在这方面，阿托伐他汀药物在酸性介质中的释放是显着的。

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