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首页> 外文期刊>Bulletin of the NYU hospital for joint diseases >Disease patterns in vasculitis - Still a mystery
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Disease patterns in vasculitis - Still a mystery

机译：血管炎的疾病模式-仍是一个谜

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In the field of autoimmunity, much has been learned from studying circulating and tissue bound immune-reactive cells, cytokines and antibodies. However, what has brought those cells to the site of injury, for most forms of vasculitis remains a mystery. Might the etiology of at least certain forms of vasculitis be related to generation of neoantigens in the native vessel, making that vessel the target of a pathogenic immune response? How might one explain organ targeting and patterns of disease that are so critical to the diagnostic process? Embryologists have demonstrated great diversity in the vasculature of different organs. Unique quantitative and qualitative features become apparent in vascular territories as early as the third week of gestation. These differences are later amplified by the effects of further development, aging, infection, spontaneous mutations and other co-morbidities. Based on data from these observations a testable hypothesis would be that many forms of vasculitis may begin with emergence of new antigens within affected vessel walls and the resulting immune response may in fact be a normal reaction to perceived foreign protein(s).
机译：在自身免疫领域，通过研究循环和组织结合的免疫反应性细胞，细胞因子和抗体，已经学到了很多东西。然而，对于大多数形式的血管炎来说，将这些细胞带到受伤部位的原因仍然是个谜。至少某些形式的血管炎的病因可能与天然血管中新抗原的产生有关，从而使该血管成为病原性免疫反应的靶标吗？如何解释对诊断过程至关重要的器官靶向和疾病模式？胚胎学家已证明不同器官的脉管系统具有极大的多样性。早在妊娠第三周，独特的定量和定性特征就在血管区域变得明显。这些差异后来通过进一步发展，衰老，感染，自发突变和其他合并症的影响而扩大。基于这些观察的数据，一个可检验的假设是，多种形式的血管炎可能始于受影响血管壁内新抗原的出现，并且由此产生的免疫反应实际上可能是对感知到的外源蛋白质的正常反应。

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