The International Society of Nephrology (ISN) and the World Health Organization (WHO) systems for classifying the various forms of lupus nephritis have significantly improved our understanding of the natural history of the disease and facilitated the development of new and effective treatments. The classification of the different manifestations of lupus nephritis is based upon light, immunofluorescent and electron microscopic changes. As shown in Table 1, the WHO system of nomenclature identifies six different classes of lupus nephritis, with classes III and IV being the "proliferative" forms of the disease. WHO class III, or focal proliferative glomerulonephritis, is defined by the presence of proliferating endocapillary cells within the glomeralar capillary loops.
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机译：国际肾脏病学会（ISN）和世界卫生组织（WHO）对各种形式的狼疮性肾炎进行分类的系统极大地提高了我们对疾病自然史的认识，并促进了新的有效治疗方法的开发。狼疮性肾炎不同表现的分类是基于光，免疫荧光和电子显微镜的变化。如表1所示，WHO的命名系统确定了六种不同类别的狼疮性肾炎，其中III类和IV类是该疾病的“增生”形式。 WHO III类或局灶性增生性肾小球肾炎的定义是肾小球毛细血管loop中存在增生的毛细血管内膜细胞。
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