Objective: Review of the literature addressing the rheumatic manifestations of various malignancies as well as of common chemotherapeutic agents. Methods: A literature search was performed to identify key articles regarding the association of rheumatic disease with malignancy. Results: Our review focused on the association of rheumatic disease with malignancy, paraneoplastic syndromes with rheumatic manifestations, and chemotherapeutic agents related to rheumatic syndromes. We have discussed the importance of a newly described autoantibody that may identify patients at risk for malignancy associated myositis. Conclusion: Based on our literature review, recommendations are suggested regarding who and how patients should be screened for malignancy when presenting with various rheumatic symptoms.
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