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首页> 外文期刊>European spine journal: official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society >Answer to the letter to the editor of F. Lucas et al. concerning 'outcome of thoracolumbar burst fractures treated with indirect reduction and fixation without fusion' by Huilin Yang, Jin-Hui Shi, Molly Ebraheim, Xiaochen Liu, Joseph Konrad, Ibrahim Husain, Tian-Si Tang, Jiayong Liu. Eur Spine J. Published online 8 August 2010
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Answer to the letter to the editor of F. Lucas et al. concerning 'outcome of thoracolumbar burst fractures treated with indirect reduction and fixation without fusion' by Huilin Yang, Jin-Hui Shi, Molly Ebraheim, Xiaochen Liu, Joseph Konrad, Ibrahim Husain, Tian-Si Tang, Jiayong Liu. Eur Spine J. Published online 8 August 2010

机译：回复给卢卡斯等人编辑的信。杨慧林，石金辉，莫莉·埃布拉海姆，刘晓晨，约瑟夫·康拉德，易卜拉欣·侯赛因，唐天思，刘嘉勇的“经间接复位固定而不融合的胸腰椎爆裂骨折的疗效”。 Eur Spine J.2010年8月8日在线发布

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We would like to thank Drs. Emery and Lucas for their interest in our paper: Outcome of Thoracolumbar Burst Fractures Treated with Indirect Reduction and Fixation without Fusion, and for bringing up some interesting points.We do agree that disc degeneration and disc injury occurs at vertebral levels adjacent to the injury level after implantation removal but without any clinical consequences.There are many factors associated with disc space changes. Agreeably, disc changes are due to adaptations to the new mechanical conditions of the vertebral column, but we do believe other factors have a role in the change of disc space height such as the non-physical effects of indirect reduction. Normally, the discs bear weight, but with indirect reduction the discs are stress shielded. Thus, diffusion, the primary means of delivering nutrition to the disc is decreased, because a normal amount of stress is needed for diffusion to occur [1]. In vitro studies of cultured disc cells have shown that abnormal pressures can influence the cells' production of polyglycoside, collagen and mRNA expression, as well as increase catabolism and disc degeneration [2, 3].
机译：我们要感谢博士。埃默里（Emery）和卢卡斯（Lucas）对我们的论文感兴趣：经间接复位和不固定融合固定治疗胸腰椎爆裂骨折的结果，并提出了一些有趣的观点。我们同意椎间盘退变和椎间盘损伤发生在与损伤水平相邻的椎骨水平去除植入物后没有任何临床后果。椎间盘间隙改变有许多因素。可以接受的是，椎间盘的改变是由于适应了新的椎体力学条件而引起的，但是我们确实相信其他因素也会影响椎间盘间隙高度的改变，例如间接复位的非物理作用。正常情况下，光盘会承受重量，但是通过间接减小，光盘会受到应力保护。因此，减少了扩散，将营养传送到椎间盘的主要方法是减少扩散，因为扩散需要正常的压力[1]。体外培养的椎间盘细胞的研究表明，异常压力会影响细胞产生多糖苷，胶原蛋白和mRNA的表达，并增加分解代谢和椎间盘的变性[2，3]。

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