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首页> 外文期刊>European psychiatry: the journal of the Association of European Psychiatrists >Physical illnesses, developmental risk factors and psychiatric diagnoses among subjects at risk of psychosis
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Physical illnesses, developmental risk factors and psychiatric diagnoses among subjects at risk of psychosis

机译：有精神病风险的受试者中的身体疾病，发育危险因素和精神病学诊断

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Background: Subjects with psychoses have significantly increased rates of physical illnesses, but the nature of the relationship remains largely unknown. Material and methods: The present study is part of the European Prediction of Psychosis Study (EPOS). Data were collected from 245 help-seeking individuals from six European centers (age 16-35) who met criteria for ultra-high risk of psychosis criteria. This paper seeks to investigate self-reported physical ill health and its associations with psychiatric symptoms and disorders, risk factors, and onset of psychosis during 48 months of follow-up. Results: In multivariate analysis, lifetime panic disorder (OR=2.43, 95%CI: 1.03-5.73), known complications during pregnancy and delivery (OR=2.81, 95%CI: 1.10-7.15), female gender (OR=2.88, 95%CI: 1.16-7.17), family history of psychosis (OR=3.08, 95%CI: 1.18-8.07), and having a relationship (OR=3.44, 95%CI: 1.33-8.94) were significantly associated with self-reported physician-diagnosed illness. In the Cox proportional hazard model we found no significant differences between those who had undergone a transition to psychosis and those who had not. Conclusions: The physical health of patients defined to be at ultra-high risk of psychosis seems to be commonly impaired and associated with female gender, marital status, complications during pregnancy and birth, lifetime panic disorder, and genetic risk of psychosis.
机译：背景：患有精神病的受试者的身体疾病发生率显着增加，但这种关系的性质在很大程度上尚不清楚。材料和方法：本研究是欧洲精神病预测研究（EPOS）的一部分。数据来自六个欧洲中心（年龄16-35岁）的245名寻求帮助的人，他们符合精神病超高风险标准。本文旨在调查在48个月的随访中自我报告的身体不适及其与精神症状和失调，危险因素以及精神病发作的关系。结果：在多变量分析中，一生的恐慌症（OR = 2.43，95％CI：1.03-5.73），怀孕和分娩期间已知的并发症（OR = 2.81，95％CI：1.10-7.15），女性（OR = 2.88， 95％CI：1.16-7.17），精神病的家族病史（OR = 3.08，95％CI：1.18-8.07）并有关联（OR = 3.44，95％CI：1.33-8.94）与自我报告医生诊断的疾病。在Cox比例风险模型中，我们发现经历过精神病发作的人与未经历过精神病的人之间没有显着差异。结论：被定义为极高精神病风险的患者的身体健康似乎通常受到损害，并与女性，婚姻状况，妊娠和分娩期间的并发症，终生恐慌症以及精神病的遗传风险相关。

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