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首页> 外文期刊>Evidence-based ophthalmology >META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS COMPARING LATANOPROST WITH BRIMONIDINE IN THE TREATMENT OF OPEN-ANGLE GLAUCOMA, OCULAR HYPERTENSION OR NORMAL-TENSION GLAUCOMA
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META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS COMPARING LATANOPROST WITH BRIMONIDINE IN THE TREATMENT OF OPEN-ANGLE GLAUCOMA, OCULAR HYPERTENSION OR NORMAL-TENSION GLAUCOMA

机译：拉坦前列素与布洛尼定比较的随机对照试验在开角型青光眼，眼压增高或正常张力性青光眼中的meta分析

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摘要

Research Objective Meta-analysis. Study Design To compare the efficacy and tolerability of latanoprost versus brimonidine Location New South Wales, Australia.Funding Source None listed.Relevant Methodology A systematic review of randomized controlled trials comparing latanoprost and brimondine, identified by searches including Medline, Embase, and Cochrane Controlled Trials Register was conducted. The results were independently assessed for eligibility and quality and extracted data. Data were synthesized (random effects model) and expressed as the absolute mean intraocular pressure (IOP) reduction difference from baseline to end point for efficacy and relative risk for adverse events. Subgroupanalysis and regression were used to explore heterogeneity according to patient characteristics, trial design, and quality. Fifteen publications reporting on 14 trials (1784 participants) were included in this analysis.
机译：研究目的荟萃分析。研究设计为了比较拉坦前列素与溴莫尼定的疗效和耐受性，澳大利亚新南威尔士州资金来源未列出相关方法对包括拉美前列素和Brimondine在内的随机对照试验的系统评价，包括Medline，Embase和Cochrane对照试验进行注册。独立评估结果的资格和质量，并提取数据。合成数据（随机效应模型），并表示为从基线到终点的绝对平均眼内压（IOP）降低差异，以了解疗效和不良事件的相对风险。根据患者的特征，试验设计和质量，使用亚组分析和回归来探索异质性。该分析包括15份报道14项试验的出版物（1784名参与者）。

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