Near instrument-free, simple molecular device for rapid detection of herpes simplex viruses

LemieuxB.; LiY.; KongH.; TangY.-W.

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Near instrument-free, simple molecular device for rapid detection of herpes simplex viruses

机译：近乎无需仪器的简单分子装置，可快速检测单纯疱疹病毒

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The first near instrument-free, inexpensive and simple molecular diagnostic device (IsoAmp ? HSV, BioHelix Corp., MA, USA) recently received US FDA clearance for use in the detection of herpes simplex viruses (HSV) in genital and oral lesion specimens. The IsoAmp HSV assay uses isothermal helicase-dependent amplification in combination with a disposable, hermetically-sealed, vertical-flow strip identification. The IsoAmp HSV assay has a total test-to-result time of less than 1.5 h by omitting the time-consuming nucleic acid extraction. The diagnostic sensitivity and specificity are comparable to PCR and are superior to culture-based methods. The near instrument-free, rapid and simple characteristics of the IsoAmp HSV assay make it potentially suitable for point-of-care testing.

机译：第一个近乎无仪器，廉价且简单的分子诊断设备（IsoAmp？HSV，美国马萨诸塞州BioHelix公司）最近获得了美国FDA批准，可用于检测生殖器和口腔病变标本中的单纯疱疹病毒（HSV）。 IsoAmp HSV分析使用等温解旋酶依赖性扩增结合一次性气密性垂直流条鉴定。通过省略费时的核酸提取，IsoAmp HSV分析的总测试时间不到1.5小时。诊断灵敏度和特异性与PCR相当，并且优于基于培养的方法。 IsoAmp HSV测定法几乎没有仪器，快速且简单的特性使其潜在地适合即时检验。

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来源
《Expert Review of Molecular Diagnostics》 |2012年第5期|共7页
作者
LemieuxB.; LiY.; KongH.; TangY.-W.;
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正文语种 eng
中图分类诊断学;
关键词
genital lesion; helicase-dependent amplification; herpes simplex virus; isothermal nucleic acid amplification; point-of-care testing; sexually transmitted disease; vertical flow test strip;

机译：生殖器病变;依赖于解旋酶的扩增;单纯疱疹病毒;等温核酸扩增;即时检验;性传播疾病;垂直流动试纸;

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专利

1. Near instrument-free, simple molecular device for rapid detection of herpes simplex viruses [J] . LemieuxB., LiY., KongH., Expert Review of Molecular Diagnostics . 2012,第5期

机译：近乎无需仪器的简单分子装置，可快速检测单纯疱疹病毒
2. Identification of an immunodominant epitope in glycoproteins B and G of herpes simplex viruses (HSVs) using synthetic peptides as antigens in assay of antibodies to HSV in herpes simplex encephalitis patients [J] . S. S. BHULLAR, N. H. CHANDAK, N. N. BAHETI, Acta Virologica: International Journal . 2014,第3期

机译：使用合成肽作为抗原，在单纯疱疹性脑炎患者的HSV抗体测定中鉴定单纯疱疹病毒（HSVs）糖蛋白B和G中的免疫优势表位
3. Rapid detection of glycoprotein G gene for the diagnosis and typing of herpes simplex virus infection in genital herpes. [J] . Fang XF, Song B, Tu YY, Sexually Transmitted Infections . 1999,第6期

机译：糖蛋白G基因的快速检测可用于生殖器疱疹的单纯疱疹病毒感染的诊断和分型。
4. Ability of a Series of Organotin Polyethers Derived from Substituted Hydroquinones to Inhibit the Vaccinia and Herpes Simplex Viruses [C] . Kimberly Shahi, Michael R. Roner, Girish Barot PMSE Symposia . 2009

机译：一系列有机素聚醚的能力来自取代的液体醌来抑制痘苗病毒和单纯疱疹病毒
5. Antiviral activities of selected Hong Kong marine algae against herpes simplex viruses and other viruses and their possible antiviral mechanisms. [D] . Zhu, Wen. 2002

机译：某些香港海藻对单纯疱疹病毒和其他病毒的抗病毒活性及其可能的抗病毒机制。
6. Rapid Sensitive and Specific Lateral-Flow Immunochromatographic Point-of-Care Device for Detection of Herpes Simplex Virus Type 2-Specific Immunoglobulin G Antibodies in Serum and Whole Blood [O] . Elisabeth I. Laderman, Emma Whitworth, Erickson Dumaual, 2008

机译：快速灵敏和特异的横向流免疫色谱法检测点设备用于检测血清和全血中的单纯疱疹病毒2型特异性免疫球蛋白G抗体
7. Rapid, Sensitive, and Specific Lateral-Flow Immunochromatographic Point-of-Care Device for Detection of Herpes Simplex Virus Type 2-Specific Immunoglobulin G Antibodies in Serum and Whole Blood▿ [O] . Laderman, Elisabeth I., Whitworth, Emma, Dumaual, Erickson, 2007

机译：快速，灵敏，特异的横向流免疫色谱法检测点设备，用于检测血清和全血中的单纯疱疹病毒2型特异性免疫球蛋白G抗体▿
8. Engineered Herpes Simplex Viruses for the Treatment of Malignant Peripheral Nerve Sheath Tumors. [R] . Markert, J. M., Gillespie, G. Y., Byer, S. J., 2015

机译：工程性单纯疱疹病毒治疗恶性周围神经鞘膜瘤。

Near instrument-free, simple molecular device for rapid detection of herpes simplex viruses

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