• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert Review of Molecular Diagnostics >KRAS mutational test for metastatic colorectal cancer patients: Not just a technical problem
【24h】

KRAS mutational test for metastatic colorectal cancer patients: Not just a technical problem

机译：转移性结直肠癌患者的KRAS突变测试：不仅是技术问题

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Evaluation of: Hamfjord J, Stangel AM, Skrede ML et al. Wobble-enhanced ARMS method for detection of KRAS and BRAF mutations. Diagn. Mol. Pathol. 20, 158-165 (2011). The identification of KRAS and BRAF mutations as predictive molecular alterations of resistance to EGF receptor monoclonal antibody therapy in metastatic colorectal cancer have significantly improved the selection of patients more likely to be eligible for the treatment with these targeted agents. Several methods are available for KRAS and BRAF mutation detection but few studies have compared different techniques, especially in the clinical setting. In this article, we contextualize the wobble-enhanced amplification refractory mutation sequencing method for the identification of KRAS and BRAF mutations with the other methodologies frequently used for the assessment of these alterations in colorectal cancer, discussing advantages and limitations over other frequently used diagnostic methods.
机译：评估：Hamfjord J，Stangel AM，Skrede ML等。摆动增强的ARMS方法，用于检测KRAS和BRAF突变。诊断大声笑Pathol。 20，158-165（2011）。将KRAS和BRAF突变鉴定为转移性结直肠癌中对EGF受体单克隆抗体治疗的耐药性的预测性分子改变，已显着改善了更可能有资格使用这些靶向药物治疗的患者的选择。有几种方法可用于KRAS和BRAF突变检测，但很少有研究比较不同的技术，尤其是在临床环境中。在本文中，我们将摆动增强扩增难治性突变测序方法与其他常用于评估大肠癌中这些变化的方法结合起来，以鉴定KRAS和BRAF突变，并讨论与其他常用诊断方法相比的优缺点。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号