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KRAS mutational test for metastatic colorectal cancer patients: Not just a technical problem

机译：转移性结直肠癌患者的KRAS突变测试：不仅是技术问题

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摘要

We have with great interest read the review by Francesca Molinari and Milo Frattini: 'KRAS mutational test for metastatic colorectal cancer patients: not just a technical problem' [1]. Their thorough review discussing the pros and cons of our wobble-enhanced amplification refractory mutation system (WE-ARMS) method for detection of KRAS and BRAF mutations in comparison to. other frequently used diagnostic methods was indeed to the point [2]. As pinpointed by the reviewers, "the authors state that each laboratory needs to establish the optimal cutoff, because it can depend on the type of sample, as well as on the method of DNA extraction". We would like to comment on this statement, because we have gained some experience from testing various other tissues since the article was published in 2011.
机译：我们非常感兴趣地阅读了Francesca Molinari和Milo Frattini的评论：“针对转移性结直肠癌患者的KRAS突变测试：不仅仅是技术问题” [1]。他们进行了详尽的综述，讨论了我们的摆动增强扩增难治性突变系统（WE-ARMS）方法与KRAS和BRAF突变检测相比的优缺点。其他经常使用的诊断方法的确是关键[2]。正如审稿人所指出的那样，“作者指出，每个实验室都需要确定最佳临界值，因为它可能取决于样品的类型以及DNA提取的方法”。我们想对此发表评论，因为自从该文章于2011年发表以来，我们已经通过测试其他各种组织获得了一些经验。

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