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首页> 外文期刊>Experimental and therapeutic medicine >Plasma orexin-A and ghrelin levels in patients with chronic obstructive pulmonary disease: Interaction with nutritional status and body composition
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Plasma orexin-A and ghrelin levels in patients with chronic obstructive pulmonary disease: Interaction with nutritional status and body composition

机译：慢性阻塞性肺疾病患者的血浆orexin-A和Ghrelin水平：与营养状况和身体成分的相互作用

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摘要

Orexin-A and ghrelin are two important polypep-tides that stimulate food intake, however, there is a lack of suffcient information concerning their plasma levels in patients with chronic obstructive pulmonary disease (COPD). The aim of the present study was to investigate the association between plasma orexin-A and ghrelin levels with food consumption and body composition in patients with stable phase COPD. In total, 40 patients (age, 44-80 years; male, 31; female 9) who were in the stable phase of COPD were included in the study. Blood samples for plasma orexin-A and ghrelin analysis were collected after 8-12 h of fasting; certain anthropometric measurements were obtained and a 24-h dietary recall was recorded. The mean plasma orexin-A levels in the male and female patients were 1.3±0.37 and 1.4±0.13 ng/ml, respectively, while the mean plasma ghrelin levels were 25.9±7.31 and 27.3±8.54 ng/ml, respectively. No signifcant correlation was observed between the body mass index and plasma orexin-A and ghrelin levels or between the plasma ghrelin levels and dietary nutrient intake (P>0.05). The plasma orexin-A levels were demonstrated to be higher in patients with a higher dietary total fbre intake (r=0.303, P=0.022). A similar correlation was observed between plasma orexin-A levels and dietary intake of soluble (r=0.033, P=0.029) and insoluble (r=0.335, P=0.024) fbre, as well as between the daily consumption of calcium and the levels of plasma orexin-A (r = 0. 0 65, P = 0. 046). Therefore, the results of the present study indicated that a positive correlation existed between dietary nutrient intake and plasma orexin-A levels in patients with COPD.
机译：Orexin-A和Ghrelin是刺激食物摄入的两个重要多肽，但是，关于慢性阻塞性肺疾病（COPD）患者血浆水平的信息不足。本研究的目的是研究稳定期COPD患者血浆orexin-A和ghrelin水平与食物消耗和身体成分之间的关​​系。总共纳入了COPD稳定期的40例患者（年龄44-80岁;男性31岁;女性9岁）。禁食8-12小时后收集血浆血浆orexin-A和ghrelin分析的血样。获得了某些人体测量数据，并记录了24小时的饮食召回。男性和女性患者的平均血浆orexin-A水平分别为1.3±0.37和1.4±0.13 ng / ml，而平均血浆生长素释放肽水平分别为25.9±7.31和27.3±8.54 ng / ml。体重指数与血浆orexin-A和ghrelin水平之间或血浆ghrelin水平与饮食营养摄入之间均未发现显着相关性（P> 0.05）。膳食总纤维摄入量较高的患者血浆血浆orexin-A水平较高（r = 0.303，P = 0.022）。血浆orexin-A水平与膳食中可溶性（r = 0.033，P = 0.029）和不溶性（r = 0.335，P = 0.024）纤维的摄入量以及每日钙摄入量与水平之间存在相似的相关性血浆orexin-A（r = 0. 0 65，P = 0. 046）。因此，本研究的结果表明，COPD患者的饮食营养摄入量与血浆orexin-A水平呈正相关。

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