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首页> 外文期刊>Experimental and therapeutic medicine >Transforming growth factor-beta 3 promotes facial nerve injury repair in rabbits
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Transforming growth factor-beta 3 promotes facial nerve injury repair in rabbits

机译：转化生长因子β3促进兔面神经损伤修复

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摘要

The present study investigated the effects of transforming growth factor (TGF)-beta 3 on the regeneration of facial nerves in rabbits. A total of 20 adult rabbits were randomly divided into three equal groups: Normal control (n=10), surgical control (n=10) and TGF-beta 3 treatment (n=10). The total number and diameter of the regenerated nerve fibers was significantly increased in the TGF-beta 3 treatment group, as compared with in the surgical control group (P<0.01). Furthermore, in the TGF-beta 3 treatment group, the epineurial repair of the facial nerves was intact and the nerve fibers, which were arranged in neat rows, were morphologically intact with visible myelin swelling. However, in the surgical control group, the epineurial repair was incomplete, as demonstrated by: Atrophic nerve fibers, partially disappeared axons and myelin of uneven thickness with fuzzy borders. Electron microscopy demonstrated that the regenerated fibers in the TGF-beta 3 treatment group were predominantly myelinated, with clear-layered myelin sheath structures and axoplasms rich in organelles. Although typical layered myelin sheath structures were observed in the surgical control group, the myelin sheaths of the myelinated nerve fibers were poorly developed and few organelles were detected in the axoplasms. Neuro-electrophysiological examination demonstrated that, as compared with the surgical control group, the latency period of the action potentials in the TGF-beta 3 treatment group were shorter, whereas the stimulus amplitudes of the action potentials were significantly increased (P<0.01). The results of the present study suggest that TGF-beta 3 may improve the regeneration of facial nerves following trauma or injury.
机译：本研究调查了转化生长因子（TGF）-β3对家兔面神经再生的影响。总共20只成年兔子被随机分为三组：正常对照组（n = 10），手术对照组（n = 10）和TGF-beta 3治疗（n = 10）。与手术对照组相比，TGF-beta 3治疗组的再生神经纤维总数和直径显着增加（P <0.01）。此外，在TGF-β3治疗组中，面神经的肾上腺修复完好无损，排列整齐的神经纤维形态完整，可见髓鞘肿胀。但是，在外科手术对照组中，肾上腺修复不完全，表现为：萎缩性神经纤维，部分消失的轴突和厚度不均且边界模糊的髓磷脂。电子显微镜显示，TGF-β3治疗组的再生纤维主要是髓鞘的，具有透明层的髓鞘结构和富含细胞器的轴质。尽管在手术对照组中观察到典型的分层髓鞘结构，但髓鞘神经纤维的髓鞘发育不良，并且在轴质中几乎没有细胞器被检测到。神经电生理检查显示，与手术对照组相比，TGF-β3治疗组的动作电位潜伏期短，而动作电位的刺激幅度却明显增加（P <0.01）。本研究的结果表明，TGF-β3可以改善创伤或损伤后面神经的再生。

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