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首页> 外文期刊>Experimental and therapeutic medicine >Role of cystatin C in renal damage and the optimum cut-off point of renal damage among patients with type 2 diabetes mellitus
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Role of cystatin C in renal damage and the optimum cut-off point of renal damage among patients with type 2 diabetes mellitus

机译：胱抑素C在2型糖尿病患者肾损害中的作用及最佳的肾损害临界值

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摘要

The aims of the present study were to evaluate the roles of serum cystatin C (SCysC) and urinary cystatin C (UCysC) in renal function impairment and investigate the optimum cut-off point for renal function impairment among patients with type 2 diabetes mellitus (DM). A total of 742 inpatients and outpatients with type 2 DM (age, 20-75 years) were enrolled in this population-based cross-sectional study. The levels of SCysC and UCysC were determined and the odds ratios (ORs) and 95% confidence interval (CIs) of the calculated risk ratios of the different renal damage indicators were obtained. The levels of UCysC, urinary β2-microglobulin (Uβ2-MG), urinary albumin (UALB) and SCysC in the renal function impairment groups were observed in the following order: GFR-C>GFR-B>GFR-A (P<0.05 or P<0.01). According to the levels of GFR were divided into 4 groups, group GFR-A ≥ 80ml/min, GFR-B group 50-80 ml/min, group Ccr-C 20-50 ml/min, group GFR-D <20 ml/min. Following adjustment for age and gender, multivariate correlation analysis results revealed that levels of Uβ2-MG, UCysC and UALB negatively correlated with the glomerular filtration rate (GFR; P<0.05 or P<0.01). In addition, the duration of DM and the levels of SCysC and serum uric acid were shown to positively correlate with the GFR (P<0.05 or P<0.01). ORs for early renal function impairment significantly increased from the DM duration category of four years (OR, 1.74; 95% CI, 1.54-1.92). Receiver operating characteristic analysis demonstrated that the optimum DM cut-off point was four years, in which 60.79% sensitivity and 69.66% specificity were observed. Therefore, UCsyC levels may be used as an efficient indicator for the evaluation of early renal function impairment among patients with type 2 DM. In addition, renal lesions may initially occur in the renal tubule and then form in the renal glomerulus of patients with type 2 DM.
机译：本研究的目的是评估血清半胱氨酸蛋白酶抑制剂C（SCysC）和尿半胱氨酸蛋白酶抑制剂C（UCysC）在肾功能损害中的作用，并探讨2型糖尿病（DM）患者肾功能损害的最佳临界点）。这项基于人群的横断面研究共纳入742名2型DM住院和门诊患者（年龄20-75岁）。确定SCysC和UCysC的水平，并获得不同肾脏损害指标的计算风险比的比值比（OR）和95％置信区间（CIs）。肾功能损害组的UCysC，尿β2-微球蛋白（Uβ2-MG），尿白蛋白（UALB）和SCysC水平按以下顺序观察：GFR-C> GFR-B> GFR-A（P <0.05或P <0.01）。根据GFR水平分为4组，GFR-A组≥80ml/ min，GFR-B组50-80ml / min，Ccr-C组20-50ml / min，GFR-D <20ml /分钟。在调整了年龄和性别之后，多元相关分析结果显示，Uβ2-MG，UCysC和UALB的水平与肾小球滤过率呈负相关（GFR; P <0.05或P <0.01）。此外，DM持续时间以及SCysC和血清尿酸水平与GFR呈正相关（P <0.05或P <0.01）。早期肾功能损害的OR从四年的DM持续时间类别显着增加（OR，1.74; 95％CI，1.54-1.92）。接收器工作特性分析表明，最佳DM截止点为四年，其中观察到60.79％的敏感性和69.66％的特异性。因此，UCsyC水平可以用作评估2型DM患者早期肾功能损害的有效指标。此外，肾损伤可能最初发生在肾小管中，然后在2型DM患者的肾小球中形成。

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