Evaluation of acute skin irritation and phototoxicity by aqueous and ethanol fractions of Angelica keiskei

Lee Sang-Han

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Evaluation of acute skin irritation and phototoxicity by aqueous and ethanol fractions of Angelica keiskei

机译：用当归的水和乙醇馏分评估急性皮肤刺激性和光毒性

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In this study, to assess whether aqueous and ethanol fractions of Angelica keiskei induce acute skin irritation and phototoxicity, acute skin irritancy and phototoxicity tests were performed. The skin of rabbits or guinea pigs was treated with these fractions (100 mg/dose) and whether the animals sustained significant skin damage was determined. The data demonstrated that the aqueous and ethanol fractions of Angelica keiskei did not induce acute toxicity in the skin of the animals, as assessed by anatomical and pathological observations. The results from the present study suggest that these aqueous and ethanol fractions of Angelica keiskei have promising potential uses as cosmetic ingredients that do not induce significant levels of skin irritation or phototoxicity.

机译：在这项研究中，为了评估当归的水和乙醇部分是否会引起急性皮肤刺激和光毒性，进行了急性皮肤刺激和光毒性测试。用这些级分（100毫克/剂量）处理兔子或豚鼠的皮肤，并确定动物是否遭受了明显的皮肤损伤。数据表明，通过解剖学和病理学观察，当归的水和乙醇馏分不会在动物皮肤中引起急性毒性。本研究的结果表明，当归的这些水和乙醇馏分作为化妆品成分具有潜在的潜在用途，不会引起明显的皮肤刺激或光毒性。

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《Experimental and therapeutic medicine》 |2013年第1期|共6页
作者
Lee Sang-Han;
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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
Angelica keiskei; skin irritancy; phototoxicity; fraction;

机译：当归;皮肤刺激性;光毒性;级分;

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1. Evaluation of acute skin irritation and phototoxicity by aqueous and ethanol fractions of Angelica keiskei [J] . Lee Sang-Han Experimental and therapeutic medicine . 2013,第1期

机译：用当归的水和乙醇馏分评估急性皮肤刺激性和光毒性
2. A prevalidation study on the in vitro skin irritation function test (SIFT) for prediction of acute skin irritation in vivo: results and evaluation of ECVAM Phase III. [J] . Heylings JR, Diot S, Esdaile DJ, Toxicology in vitro: an international journal published in association with BIBRA . 2003,第2期

机译：体外皮肤刺激功能测试（SIFT）预测体内急性皮肤刺激的预验证研究：ECVAM III期的结果和评估。
3. Assessment of the skin irritation potential of chemicals by using the SkinEthic reconstructed human epidermal model and the common skin irritation protocol evaluated in the ECVAM skin irritation validation study. [J] . Kandarova H, Liebsch M, Schmidt E, Alternatives to laboratory animals: ATLA . 2006,第4期

机译：通过使用SkinEthic重建的人表皮模型和在ECVAM皮肤刺激验证研究中评估的常见皮肤刺激方案，评估化学药品对皮肤的刺激潜力。
4. Assessment of Acute Skin Irritation in Rabbits Using Electrical Impedance Model [C] . Ferreira, D. M., Silva, Engineering in Medicine and Biology Society, 2006 Annual International Conference of the IEEE . 2006

机译：用电阻抗模型评估兔的急性皮肤刺激
5. Evaluation of parameters influencing skin irritation and design criteria for prolonged pressure exposure [D] . Chang, Wunching 1997

机译：评估影响皮肤刺激的参数和延长压力暴露的设计标准
6. Evaluation of acute skin irritation and phototoxicity by aqueous and ethanol fractions of Angelica keiskei [O] . SANG-HAN LEE -1

机译：当归水和乙醇组分对急性皮肤刺激和光毒性的评价
7. Comparison of the toxicity of aqueous and ethanol fractions of Angelica keiskei leaf using the eye irritancy test [O] . HYEONG-U SON, EUN-KYUNG YOON, YONG-SOO CHA, 2012

机译：用眼睛刺激性试使对照叶片含水和乙醇分数毒性的比较
8. Information on Acute Oral Toxicity, Acute Inhalation Toxicity, Acute Dermal Toxicity, Eye Irritation, Skin Irritation, Skin Sensitization, Repeat Dose Toxicity, Mutagenicity/Genotoxicity, Reproductive/Developmental Toxicity Screening and Reproductive Scre [R] . 2011

机译：有关急性口服毒性，急性吸入毒性，急性皮肤毒性，眼睛刺激，皮肤刺激，皮肤过敏，重复剂量毒性，致突变性/遗传毒性，生殖/发育毒性筛查和生殖性疾病的信息

Evaluation of acute skin irritation and phototoxicity by aqueous and ethanol fractions of Angelica keiskei

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