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Analysis of the expression of KIR and HLA-Cw in a Northeast Han population

机译：东北汉族人群KIR和HLA-Cw的表达分析

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The aim of this study was to investigate the expression of the human leukocyte antigen (HLA)-Cw and killer cell immunoglobulin-like receptor (KIR) genes in a Jilin Han population and to provide a theoretical basis for further studies of their roles in disease. A total of 154 unpaid Jilin Han blood donors were selected and KIR and HLA-Cw genotyping was performed using PCR-SSP. Recognition of HLA-Cw and the corresponding activatory or inhibitory KIR receptor was distinguished according to the identification of HLA-Cw and KIR. In the present study, the expression frequency of HLA-C2(Lys80)+2DL1 was 27.27%, HLA-C1(Asn80)+2DL2/2DL3 was 68.83%, 2DS2+HLA-C1(Asn80) was 9.74% and 2DS1+HLA-C2(Lys80) was 9.74%. Of the individuals in the study, 72.08% expressed only KIR2DL1 without HLA-Cw, 21.43% expressed only KIR2DS1 without HLA-Cw(Lys)-KIR2DL1 and 2.60% expressed only KIR2DS2 without HLA-Cw(Asn)-KIR2DL2/L3. In conclusion, the expression of inhibitory HLA-Cw-KIR is higher than the expression of activating HLA-Cw-KIR and approximately 20% of the individuals separately expressed the activated HLA-Cw-KIR in the Jilin Han population in the present study.
机译：这项研究的目的是调查吉林汉族人群中人类白细胞抗原（HLA）-Cw和杀伤细胞免疫球蛋白样受体（KIR）基因的表达，并为进一步研究其在疾病中的作用提供理论依据。 。总共选择了154名吉林汉族无偿献血者，并使用PCR-SSP进行了KIR和HLA-Cw基因分型。根据对HLA-Cw和KIR的鉴定，区分了HLA-Cw和相应的活化或抑制性KIR受体的识别。在本研究中，HLA-C2（Lys80）+ 2DL1的表达频率为27.27％，HLA-C1（Asn80）+ 2DL2 / 2DL3的表达频率为68.83％，2DS2 + HLA-C1（Asn80）的表达频率为9.74％，2DS1 + HLA -C 2（Lys80）为9.74％。在研究的个体中，72.08％仅表达不具有HLA-Cw的KIR2DL1，21.43％仅表达不具有HLA-Cw（Lys）-KIR2DL1的KIR2DS1，2.60％仅表达不具有HLA-Cw（Asn）-KIR2DL2 / L3的KIR2DS2。总之，在本研究中，抑制性HLA-Cw-KIR的表达高于激活HLA-Cw-KIR的表达，大约20％的个体在吉林汉族人群中单独表达了激活的HLA-Cw-KIR。

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