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首页> 外文期刊>Experimental and therapeutic medicine >IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study
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IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study

机译：IGF2BP2 rs11705701多态性与中国人群的糖尿病前期相关：基于人群的病例对照研究

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摘要

Associations between insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) rs11705701, insulin receptor substrate 1 rs7578326, gastric inhibitory polypeptide receptor rs10423928 and transcription factor 7-like 2 rs12255372 gene polymorphisms with prediabetes and type 2 diabetes (T2D) have not been evaluated in the Han Chinese population. These four genetic variants were investigated for their associations with prediabetes and T2D among 490 unrelated patients with T2D, 471 patients with prediabetes and 575 healthy controls. Sequenom MassARRAY software was used to genotype the patients for these variants. The Generalized Multifactor Dimensionality Reduction method was used to analyze the gene-gene and gene-environment interactions. A breakdown analysis by gender revealed a significant association of IGF2BP2 rs11705701 with prediabetes under the dominant genetic model in females following application of the Bonferroni correction (odds ratio = 0.26; 95% confidence interval = 0.10-0.67; P=0.005). However, no significant associations were reported between any of the other three polymorphisms and T2D under any genetic models. Furthermore, there were no statistically significant gene-gene or gene-environment interactions when evaluated with the above association tests. The present case-control study reveals a significant association between IGF2BP2 rs11705701 and prediabetes in female patients.
机译：胰岛素样生长因子2 mRNA结合蛋白2（IGF2BP2）rs11705701，胰岛素受体底物1 rs7578326，胃抑制性多肽受体rs10423928和转录因子7样2 rs12255372基因多态性与前驱糖尿病和2型糖尿病（T2D）之间没有关联在汉族人群中进行了评估。在490名无关的T2D患者，471名糖尿病前期患者和575名健康对照者中，研究了这四个遗传变异与糖尿病和T2D的关联。使用Sequenom MassARRAY软件对这些变体的患者进行基因分型。广义多维度降维方法用于分析基因-基因和基因-环境的相互作用。按性别进行的细分分析显示，在应用Bonferroni校正后，女性的主导遗传模型下IGF2BP2 rs11705701与前驱糖尿病显着相关（赔率= 0.26; 95％置信区间= 0.10-0.67; P = 0.005）。但是，在任何遗传模型下，其他三个多态性与T2D之间均未发现显着关联。此外，当用上述关联测试评估时，没有统计上显着的基因-基因或基因-环境相互作用。本病例对照研究揭示了女性患者中IGF2BP2 rs11705701与糖尿病前期之间的显着关联。

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