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首页> 外文期刊>Experimental nephrology >Role of the PDZ scaffolding protein in tubule cells in maintenance of polarised function.
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Role of the PDZ scaffolding protein in tubule cells in maintenance of polarised function.

机译：PDZ支架蛋白在肾小管细胞中在维持极化功能中的作用。

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摘要

Polarized tubule epithelial cell functions are dependent on correct delivery of effector proteins to the target apical or basolateral plasma membrane and associated cortical cytoskeleton. PDZ (Postsynaptic density protein 95/Drosophila Disks large/Zona occludens-1) domain-containing proteins have been identified as playing a critical role in membrane trafficking and sorting of ion transporters, receptors and other signalling proteins. These scaffolding proteins coordinate the assembly of functional plasma membrane multiprotein complexes, through PDZ domain binding to a consensus amino acid motif within the carboxyl-terminus of target proteins. The organization of these proteins into submembranous complexes may facilitate downstream signalling. Although several epithelial PDZ proteins that bind to a number of important mammalian proteins have been isolated, in many cases the significance of these interactions is unclear. However, the epithelial PDZ domain-containing Na(+)/H(+) exchanger regulatory factor tethers the Na(+)/H(+) exchanger and cystic fibrosis transmembrane regulator Cl(-) channel within an apical plasma membrane signalling complex, and has been shown to regulate the activity of these proteins. This article reviews the current evidence that supports a central role for the PDZ protein in the regulation of polarized tubule cell functions, such as vectorial solute transport. Copyright 2002 S. Karger AG, Basel
机译：极化的小管上皮细胞功能取决于效应蛋白向靶心顶或基底外侧质膜及相关皮质细胞骨架的正确递送。含PDZ（突触后密度蛋白95 /果蝇盘大/ Zona occludens-1）的域蛋白已被确认在膜运输和离子转运蛋白，受体和其他信号蛋白的分类中起着至关重要的作用。这些支架蛋白通过PDZ域与靶蛋白羧基末端内的共有氨基酸基序结合来协调功能性质膜多蛋白复合物的组装。这些蛋白质组织成膜下复合物可以促进下游信号传导。尽管已分离出与多种重要哺乳动物蛋白结合的几种上皮PDZ蛋白，但在许多情况下，这些相互作用的重要性尚不清楚。但是，包含上皮PDZ域的Na（+）/ H（+）交换子调节因子将Na（+）/ H（+）交换子和囊性纤维化跨膜调节子Cl（-）通道束缚在顶端质膜信号传导复合体内，并且已经显示出可以调节这些蛋白质的活性。本文回顾了目前的证据，这些证据支持PDZ蛋白在极化小管细胞功能（如矢量溶质运输）的调节中的核心作用。版权所有2002 S. Karger AG，巴塞尔

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