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首页> 外文期刊>Experimental Brain Research >Trace eyeblink conditioning in human subjects with cerebellar lesions.
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Trace eyeblink conditioning in human subjects with cerebellar lesions.

机译：患有小脑病变的人类受试者中的微量眨眼条件。

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摘要

Trace eyeblink conditioning was investigated in 31 patients with focal cerebellar lesions and 19 age-matched controls. Twelve patients presented with lesions including the territory of the superior cerebellar artery (SCA). In 19 patients lesions were restricted to the territory of the posterior inferior cerebellar artery (PICA). A 3D magnetic resonance imaging was used to determine the extent of the cortical lesion and possible involvement of cerebellar nuclei. Eyeblink conditioning was performed using a 40 ms tone as conditioned stimulus (CS) followed by a stimulus free trace-interval of 400 ms and a 100 ms air-puff as unconditioned stimulus (US). In SCA patients with lesions including parts of the cerebellar interposed nucleus trace eyeblink conditioning was significantly impaired. Pure cortical lesions of the superior cerebellum were not sufficient to reduce acquisition of trace conditioned eyeblink responses. PICA patients were not impaired in trace eyeblink conditioning. Consistent with animal studies the findings of the present human lesion study suggest that, in addition to forebrain areas, the interposed nucleus is of importance in trace eyeblink conditioning. Although cortical cerebellar areas appear less important in trace compared with delay eyeblink conditioning, the present data strengthen the view that cerebellar structures contribute to different forms of eyeblink conditioning paradigms.
机译：对31例局灶性小脑病变患者和19例年龄匹配的对照者进行了微量眼眨条件的研究。 12名患者出现病变，包括小脑上动脉（SCA）的区域。在19例患者中，病变仅限于小脑后下动脉（PICA）的区域。使用3D磁共振成像来确定皮层病变的程度和小脑核的可能累及。使用40 ms调作为条件刺激（CS），然后进行400 ms的无刺激跟踪间隔和100 ms吹气作为非条件刺激（US），进行眨眼调节。在有病变的SCA患者中，包括部分小脑插入的核，痕迹眨眼条件明显受损。小脑上皮的纯皮损不足以减少痕量条件性眨眼反应的获得。 PICA患者在微量眨眼条件下没有受损。与动物研究一致，本次人类病变研究的结果表明，除前脑区域外，插入的核在微量眨眼调节中也很重要。尽管与延迟眨眼调节相比，皮质小脑区域在痕迹上似乎不那么重要，但本数据进一步证明了小脑结构有助于形成不同形式的眨眼调节范例。

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