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首页> 外文期刊>Experimental Brain Research >The role of the basal ganglia in action imitation: Neuropsychological evidence from Parkinson's disease patients
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The role of the basal ganglia in action imitation: Neuropsychological evidence from Parkinson's disease patients

机译：基底神经节在动作模仿中的作用：帕金森氏病患者的神经心理学证据

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Though previous studies have suggested that the basal ganglia are necessarily involved in action imitation, their precise role is unclear. An important source of evidence concerns patients with Parkinson's disease (PD) who suffer basal ganglia impairments. Some studies report poor execution of observed meaningful (MF) transitive (tool-related) actions but normal performance with intransitive (non-tool-related) MF and meaningless (ML) actions (Leiguarda et al. in Brain 120:75-90, 1997; Leiguarda 2001 in Neuroimage 14:137-141). In other cases, though, patients with lesions involving the basal ganglia appear impaired in imitating ML as compared to meaningful MF transitive pantomimes. Here, we tested a group of PD patients in a full 2 × 2 design with MF transitive and intransitive pantomimes and matched ML movements. PD patients generated higher scores when imitating MF transitive actions than ML-matched actions. On the other hand, ML than MF intransitive actions did not differ significantly. The performance of the patients on imitating ML transitive actions also correlated with their performance on the Corsi block test of visuospatial memory and their scores at the test of verbal fluency for phonemic categories (FAS) while MF intransitive actions correlated with FAS and the neurological evaluation (UPDRS) The results are discussed in terms of the factors that load on visual memory for action reproduction, as well as the possible role of the basal ganglia in communicative actions (for MF intransitive actions).
机译：尽管以前的研究表明基底节一定参与了动作模仿，但其确切作用尚不清楚。重要的证据来源涉及患有基底神经节损伤的帕金森氏病（PD）患者。一些研究报告说，观察到的有意义的（MF）传递（工具相关）动作执行不力，但是具有不传递（非工具相关）MF和无意义（ML）动作的正常表现（Leiguarda等人，Brain 120：75-90， 1997; Leiguarda 2001，神经影像14：137-141）。但是，在其他情况下，与有意义的MF传递哑剧相比，具有累及基底神经节病变的患者在模仿ML方面似乎受损。在这里，我们以MF传递和不传递哑剧以及匹配的ML运动测试了一组完全2×2设计的PD患者。当模仿MF传递动作时，PD患者比ML匹配动作产生更高的分数。另一方面，ML比MF的不及物动词没有显着差异。患者模仿ML传递动作的表现还与他们在视觉空间记忆的Corsi块检验以及语音类别（FAS）的口语流利测试中的得分相关，而MF传递性动作与FAS和神经系统评价相关（ （UPDRS）将根据视觉记忆中用于动作再现的因素以及基底神经节在交流动作中（对于MF不及格动作）的可能作用来讨论结果。

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