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Gamma band activity in the RAS-intracellular mechanisms

机译：RAS细胞内机制中的伽玛带活动

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Gamma band activity participates in sensory perception, problem solving, and memory. This review considers recent evidence showing that cells in the reticular activating system (RAS) exhibit gamma band activity, and describes the intrinsic membrane properties behind such manifestation. Specifically, we discuss how cells in the mesopontine pedunculopontine nucleus, intralaminar parafascicular nucleus, and pontine SubCoeruleus nucleus dorsalis all fire in the gamma band range when maximally activated, but no higher. The mechanisms involve high-threshold, voltage-dependent P/Q-type calcium channels, or sodium-dependent subthreshold oscillations. Rather than participating in the temporal binding of sensory events as in the cortex, gamma band activity in the RAS may participate in the processes of preconscious awareness and provide the essential stream of information for the formulation of many of our actions. We address three necessary next steps resulting from these discoveries: an intracellular mechanism responsible for maintaining gamma band activity based on persistent G-protein activation, separate intracellular pathways that differentiate between gamma band activity during waking versus during REM sleep, and an intracellular mechanism responsible for the dysregulation in gamma band activity in schizophrenia. These findings open several promising research avenues that have not been thoroughly explored. What are the effects of sleep or REM sleep deprivation on these RAS mechanisms? Are these mechanisms involved in memory processing during waking and/or during REM sleep? Does gamma band processing differ during waking versus REM sleep after sleep or REM sleep deprivation?
机译：伽玛乐队活动参与感觉知觉，问题解决和记忆。这项审查认为最近的证据表明网状激活系统（RAS）中的细胞表现出伽玛带活动，并描述这种表现背后的固有膜特性。具体来说，我们讨论最大激活时，中桥骨足桥神经核，层内束旁核和桥脑背小核背侧核中的细胞在γ谱带范围内均会发射，但不会更高。该机制涉及高阈值，电压依赖性P / Q型钙通道或钠依赖性亚阈值振荡。 RAS中的伽玛谱带活动可能不参与皮质中的感觉事件的时间绑定，而可能参与前知觉的过程，并为我们许多行动的制定提供必要的信息流。我们研究了由这些发现所导致的三个必要的下一步：基于持久性G蛋白活化的负责维持伽玛谱带活动的细胞内机制，区分醒来与快速眼动睡眠期间的伽玛谱带活动的单独的胞内途径以及负责精神分裂症的γ带活动失调。这些发现打开了一些尚未被彻底探索的有前途的研究途径。睡眠或快速眼动睡眠剥夺对这些RAS机制有什么影响？这些机制是否在唤醒和/或REM睡眠期间参与内存处理？醒来后的γ波段处理与睡眠或剥夺REM睡眠后的REM睡眠是否有所不同？

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