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首页> 外文期刊>Experimental Brain Research >Immunoreactivity for calretinin and calbindin in the vestibular nuclear complex of the monkey.
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Immunoreactivity for calretinin and calbindin in the vestibular nuclear complex of the monkey.

机译：Calretinin和calbindin在猴子前庭核复合物中的免疫反应性。

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摘要

Immunoreactivity to calcium-binding proteins has been a useful extension to cytoarchitectonics in defining the organization of many central nervous system regions. Previously we found subdivisions of the cat medial vestibular nucleus (MVe) defined by immunoreactivity to the calcium-binding proteins, calretinin and calbindin. Here we report similar subdivisions in both the squirrel and the macaque monkey. Calretinin immunoreactivity reveals a small area of cells and processes located dorsally in the MVe. In the anterior-posterior direction these cells extend over less than half of the nucleus. This area is not distinct in Nissl-stained sections. Elsewhere in the vestibular nuclear complex (VNC) and in the nucleus prepositus hypoglossi (PrH) there are scattered labeled cells. Immunoreactivity for calbindin shows a small patch of dense fiber label at the border of MVe and PrH, and a patchy distribution in the rest of the VNC that changes at different anterior-posterior levels. There are also calbindin-labeled cells in the underlying reticular formation over a very restricted anterior-posterior extent in both squirrel and macaque monkey. The dendrites of some of these cells can be followed into PrH, and data from other studies suggests that they may contribute to vestibular-oculomotor function. Scattered cells in the VNC are densely outlined by calbindin-labeled terminals, suggesting a major drive from the calbindin-labeled fiber input. These findings, along with observations from rodents and cats, suggest that there are subdivisions of the MVe defined by calcium-binding proteins that are homologous across rodents, cats, and New World and Old World monkeys.
机译：在定义许多中枢神经系统区域的组织中，对钙结合蛋白的免疫反应性一直是细胞结构学的有用扩展。以前，我们发现猫前庭内侧核（MVe）的细分是由对钙结合蛋白，钙调蛋白和钙结合蛋白的免疫反应性定义的。在这里，我们在松鼠和猕猴中都报告了类似的细分。 Calretinin免疫反应性揭示了MVe背面的一小部分细胞和过程。这些细胞在前后方向上延伸不到细胞核的一半。 Nissl染色部分中该区域并不明显。在前庭核复合体（VNC）和垂体前丘核（PrH）的其他位置，有分散的标记细胞。 Calbindin的免疫反应性在MVe和PrH的边界处显示一小块致密的纤维标记，在VNC的其余部分中出现斑块状分布，并在不同的前后水平上变化。在松鼠和猕猴中，在非常有限的前后范围内，在潜在的网状结构中还存在钙结合蛋白标记的细胞。其中一些细胞的树突可以被追踪到PrH中，其他研究的数据表明它们可能有助于前庭动眼功能。 VNC中分散的细胞被钙结合蛋白标记的末端密集地勾勒出轮廓，这表明钙结合蛋白标记的纤维输入是主要驱动力。这些发现以及对啮齿动物和猫的观察表明，MVe的细分由钙结合蛋白定义，而钙结合蛋白在啮齿动物，猫以及“新世界和旧世界”猴子之间是同源的。

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