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首页> 外文期刊>Experimental Brain Research >Dorsal subcoeruleus nucleus (SubCD) involvement in context-associated fear memory consolidation
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Dorsal subcoeruleus nucleus (SubCD) involvement in context-associated fear memory consolidation

机译：背基底膜下核（SubCD）参与与上下文相关的恐惧记忆巩固

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The neurobiological mechanisms of emotional memory processing can be investigated using classical fear conditioning as a model system, and evidence from multiple lines of research suggests that sleep influences consolidation of emotional memory. In rodents, some of this evidence comes from a common finding that sleep deprivation from 0 to 6 h after fear conditioning training impairs processing of conditioned fear memory. Here, we show that during a 6-h session of sleep-wake (S-W) recording, immediately after a session of context-associated fear conditioning training, rats spent more time in wakefulness (W) and less time in slow-wave sleep (SWS) and rapid eye movement (REM) sleep. This context-associated fear conditioning training-induced reduction in SWS lasts for 2 h, and the REM sleep reduction lasts throughout the entire 6-h post-training S-W recording period. Interestingly, these reductions in SWS and REM sleep during this 6-h period did not impair memory consolidation for context-associated fear conditioning. The results of this study show, for the first time, that lesions within the dorsal part of the subcoeruleus nucleus (SubCD), which were unintentionally caused by the implantation of bipolar recording electrodes, impair consolidation of context-associated fear conditioning memory. Together, the results of these experiments suggest that emotional memory processing associated with fear conditioning can be completed successfully within less than a normal amount of sleep, but it requires a structurally and functionally intact SubCD, an area in the brain stem where phasic pontine wave (P-wave) generating cells are located.
机译：可以使用经典恐惧条件作为模型系统来研究情绪记忆处理的神经生物学机制，并且来自多方面研究的证据表明睡眠会影响情绪记忆的巩固。在啮齿类动物中，一些证据来自一个共同的发现，即恐惧条件训练后0-6小时的睡眠剥夺会削弱条件恐惧记忆的处理。在这里，我们表明，在6小时的睡眠唤醒（SW）记录过程中，在进行了一次与情景相关的恐惧条件训练之后，大鼠在觉醒（W）上花费的时间更多，而在慢波睡眠中花费的时间更少（ SWS）和快速眼动（REM）睡眠。这种与情境相关的恐惧调节训练导致的SWS减少持续2小时，而REM睡眠减少持续整个训练后6小时的S-W记录期间。有趣的是，在这6小时内SWS和REM睡眠的这些减少并没有损害与情境相关的恐惧条件的记忆巩固。这项研究的结果首次显示，由于植入双极记录电极无意引起了在蓝小脑核（SubCD）背侧部分的损伤，损害了与环境相关的恐惧条件记忆的巩固。总之，这些实验的结果表明，与恐惧条件相关的情绪记忆处理可以在少于正常睡眠量的情况下成功完成，但需要结构和功能上完整的SubCD，即脑干中的一个阶段性桥脑波（定位P波）生成单元。

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