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首页> 外文期刊>Experimental Brain Research >Sleep enhances inhibitory behavioral control in discrimination learning in rats
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Sleep enhances inhibitory behavioral control in discrimination learning in rats

机译：睡眠增强大鼠歧视性学习中的抑制行为控制

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Sleep supports the consolidation of memory, and it has been proposed that this enhancing effect of sleep pertains in particular to memories which are encoded under control of prefrontal-hippocampal circuitry into an episodic memory system. Furthermore, repeated reactivation and transformation of such memories during sleep are thought to promote the de-contextualization of these memories. Here, we aimed to establish a behavioral model for the study of such sleep-dependent system consolidation in rats, using a googo conditional discrimination learning task known to essentially depend on prefrontal- hippocampal function. Different groups of rats were trained to criterion on this task and, then, subjected to 80-min retention intervals filled with spontaneous morning sleep, sleep deprivation, or spontaneous evening wakefulness. In a subsequent test phase, the speed of relearning of the discrimination task was examined as indicator of memory, whereby rats were either tested in the same context as during training or in a different context. Sleep promoted relearning of the conditional discrimination task, and this effect was similar for testing memory in the same or different context (p < 0.001). Independent of sleep and wakefulness during the retention interval, animals showed faster relearning when tested in the same context as during learning, compared with testing in a different context (p < 0.001). The benefitting effect of sleep on discrimination learning was primarily due to an enhancing effect on response suppression during the nogo stimulus. We infer from these results that sleep enhances memory for inhibitory behavioral control in a generalized context-independent manner and thereby might eventually also contribute to the abstraction of schema-like representations.
机译：睡眠支持记忆的巩固，并且已经提出，睡眠的这种增强效果尤其涉及在前额海马电路的控制下被编码为情节性记忆系统的记忆。此外，人们认为在睡眠期间反复激活和转换此类记忆可促进这些记忆的去上下文化。在这里，我们旨在建立一个行为模型，用于研究大鼠的这种依赖睡眠的系统巩固，使用已知主要依赖于前额海马功能的go / nogo条件辨别学习任务。对不同组的大鼠进行训练以评估其任务，然后进行80分钟的保留间隔，充实自发的早晨睡眠，睡眠剥夺或自发的夜间清醒。在随后的测试阶段中，将重新学习区分任务的速度作为记忆的指标，从而在与训练期间相同的环境中或在不同的环境中对大鼠进行了测试。睡眠促进了条件歧视任务的重新学习，对于在相同或不同背景下测试记忆，这种效果是相似的（p <0.001）。与在保持学习间隔期间的睡眠和清醒无关，与在不同学习环境中进行的测试相比，在不同学习环境中进行测试的动物显示出更快的重新学习（p <0.001）。睡眠对歧视性学习的有益作用主要是由于在nogo刺激过程中对反应抑制的增强作用。我们从这些结果推断出，睡眠以广义的上下文无关的方式增强了抑制行为控制的记忆，从而最终可能也有助于模式表示的抽象。

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