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首页> 外文期刊>Experimental Neurology >Pairing tone trains with vagus nerve stimulation induces temporal plasticity in auditory cortex
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Pairing tone trains with vagus nerve stimulation induces temporal plasticity in auditory cortex

机译：将音调与迷走神经刺激配对可诱导听觉皮层的时间可塑性

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摘要

The selectivity of neurons in sensory cortex can be modified by pairing neuromodulator release with sensory stimulation. Repeated pairing of electrical stimulation of the cholinergic nucleus basalis, for example, induces input specific plasticity in primary auditory cortex (A1). Pairing nucleus basalis stimulation (NBS) with a tone increases the number of A1 neurons that respond to the paired tone frequency. Pairing NBS with fast or slow tone trains can respectively increase or decrease the ability of A1 neurons to respond to rapidly presented tones. Pairing vagus nerve stimulation (VNS) with a single tone alters spectral tuning in the same way as NBS-tone pairing without the need for brain surgery. In this study, we tested whether pairing VNS with tone trains can change the temporal response properties of A1 neurons. In na?ve rats, A1 neurons respond strongly to tones repeated at rates up to 10. pulses per second (pps). Repeatedly pairing VNS with 15. pps tone trains increased the temporal following capacity of A1 neurons and repeatedly pairing VNS with 5. pps tone trains decreased the temporal following capacity of A1 neurons. Pairing VNS with tone trains did not alter the frequency selectivity or tonotopic organization of auditory cortex neurons. Since VNS is well tolerated by patients, VNS-tone train pairing represents a viable method to direct temporal plasticity in a variety of human conditions associated with temporal processing deficits.
机译：感觉皮质中神经元的选择性可以通过将神经调节剂释放与感觉刺激配对来改变。例如，胆碱能核基础的电刺激的重复配对在初级听觉皮层（A1）中诱导输入比可塑性。将基核刺激（NBS）与音调配对会增加对配对音调频率作出响应的A1神经元的数量。将NBS与快速或慢速音调配对可以分别增加或减少A1神经元对快速呈现的音调做出反应的能力。将迷走神经刺激（VNS）与单音配对可以以与NBS音配对相同的方式改变频谱调谐，而无需进行脑部手术。在这项研究中，我们测试了将VNS与音调配对是否可以改变A1神经元的时间响应特性。在幼稚的大鼠中，A1神经元对以每秒10个脉冲（pps）的速率重复的音调产生强烈的反应。将VNS与15 pps音调反复配对会增加A1神经元的时间跟随能力，而将VNS与5 pps音调反复配对会降低A1神经元的暂时跟随能力。将VNS与音调配对不会改变听觉皮层神经元的频率选择性或音调组织。由于患者对VNS的耐受性良好，因此VNS音调配对代表了一种在与时间处理缺陷相关的各种人类疾病中指导时间可塑性的可行方法。

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