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Role of myelin-associated inhibitors in axonal repair after spinal cord injury

机译:髓鞘相关抑制剂在脊髓损伤后轴突修复中的作用

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摘要

Myelin-associated inhibitors of axon growth, including Nogo, MAG and OMgp, have been the subject of intense research. A myriad of experimental approaches have been applied to investigate the potential of targeting these molecules to promote axonal repair after spinal cord injury. However, there are still conflicting results on their role in axon regeneration and therefore a lack of a cohesive mechanism on how these molecules can be targeted to promote axon repair. One major reason may be the lack of a clear definition of axon regeneration in the first place. Nevertheless, recent data from genetic studies in mice indicate that the roles of these molecules in CNS axon repair may be more intricate than previously envisioned.
机译:髓磷脂相关的轴突生长抑制剂,包括Nogo,MAG和OMgp,已成为研究的重点。无数的实验方法已被用于研究靶向这些分子以促进脊髓损伤后轴突修复的潜力。但是,关于它们在轴突再生中的作用仍然存在相互矛盾的结果,因此在如何靶向这些分子以促进轴突修复方面缺乏内聚机制。一个主要原因可能是一开始缺乏轴突再生的明确定义。然而,来自小鼠遗传学研究的最新数据表明,这些分子在中枢神经系统轴突修复中的作用可能比以前设想的更为复杂。

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