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首页> 外文期刊>Experimental Neurology >Altered ventral striatal activation during reward and punishment processing in premanifest Huntington's disease: A functional magnetic resonance study
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Altered ventral striatal activation during reward and punishment processing in premanifest Huntington's disease: A functional magnetic resonance study

机译：表现为亨廷顿氏病的奖惩过程中腹侧纹状体激活的改变：功能性磁共振研究

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Recent research using various neuroimaging methods revealed the crucial role of the striatum concerning the neuropathology of Huntington's disease. Degenerative changes located in the basal ganglia are already observable in premanifest stages of Huntington's disease (pre-HD), i.e., before the onset of manifest motor symptoms. Although the impact of the striatum on reward and punishment processing is well-established in healthy subjects, these processes have not been investigated in manifest and premanifest HD subjects using functional magnetic resonance imaging (fMRI) so far.We used the Monetary Incentive Delay Task to investigate valence discrimination in terms of rewarding and punishing cues in 30 pre-HD and 15 healthy subjects. According to the probability of disease onset within the next 5years, pre-HD subjects were categorized as either near to motor symptom onset (pre-HD near; 9.9 [±2.91] years to onset) or far from manifest disease onset (pre-HD far; 23.49 [±5.99] years to onset).Compared to pre-HD far and healthy subjects, pre-HD near subjects showed a disturbed neuronal differentiation between reward and control anticipation located in the left ventral striatum. In contrast to pre-HD far and healthy subjects, no significant ventral striatal discrimination between punishing and control cues was detected in pre-HD near subjects.In the present study, we demonstrated for the first time significant differences in valence discrimination in pre-HD near subjects compared to pre-HD far subjects and healthy controls. Altered reward and punishment processing could therefore reflect a motivational deficit that may contribute to the pathogenesis of Huntington's disease.
机译：最近使用各种神经影像学方法的研究揭示了纹状体在亨廷顿氏病神经病理学中的关键作用。在亨廷顿舞蹈病（HD前期）的预示阶段，即在明显的运动症状发作之前，已经可以观察到位于基底神经节的变性变化。尽管纹状体对奖惩过程的影响在健康受试者中已广为人知，但迄今为止，尚无功能性磁共振成像（fMRI）在明显和预示高清受试者中研究这些过程。从奖励和惩罚线索方面调查30名HD前和15名健康受试者的化价歧视。根据未来5年内疾病发作的可能性，将HD前期受试者分类为接近运动症状发作（HD前期接近;发病9.9 [±2.91]年）或远离明显疾病发作（HD前）远;发病前23.49 [±5.99]年。与HD前远和健康受试者相比，HD前近受试者显示位于左腹纹状体的奖励和控制预期之间的神经元分化受到干扰。与HD之前的远距离健康受试者相比，HD之前的近距离受试者没有在惩罚和控制线索之间发现显着的腹侧纹状体歧视。与高清前的远距离对象和健康对照相比，近距离对象更是如此。因此，改变的奖励和惩罚过程可能反映出可能导致亨廷顿氏病发病机理的动机缺陷。

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