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首页> 外文期刊>Experimental Neurology >Magnetic resonance imaging characterization of different experimental autoimmune encephalomyelitis models and the therapeutic effect of glatiramer acetate.
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Magnetic resonance imaging characterization of different experimental autoimmune encephalomyelitis models and the therapeutic effect of glatiramer acetate.

机译：不同实验性自身免疫性脑脊髓炎模型的磁共振成像特征以及醋酸格拉替雷的治疗效果。

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The roles of inflammation and degeneration as well as of gray matter abnormalities in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are controversial. We analyzed the pathological manifestations in two EAE models, the chronic oligodendrocyte glycoprotein (MOG)-induced versus the relapsing-remitting proteolipid protein (PLP)-induced, along the disease progression, using advanced magnetic resonance imaging (MRI) parameters. The emphasis of this study was the overall assessment of the whole brain by histogram analysis, as well as the detection of specific affected regions by voxel based analysis (VBA) using quantitative T2, magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI). Brains of EAE-inflicted mice from both models revealed multiple white and gray matter areas with significant changes from na?ve mice for all MRI parameters. Ventricle swelling was more characteristic to the PLP-induced model. Decreased MTR values and increased apparent diffusion coefficient (ADC) were observed mainly in MOG-induced EAE, indicative of macromolecular loss and structural CNS damage involvement in the chronic disease. The MS drug glatiramer acetate (GA), applied either as prevention or therapeutic treatment, affected all the MRI pathological manifestations, resulting in reduced T2 values and ventricle volume, elevated MTR and decreased ADC, in comparison to untreated EAE-inflicted mice. In accord, immunohistochemical analysis indicated less histological damage and higher amount of proliferating oligodendrocyte progenitor cells after GA treatment. The higher brain tissue integrity reflected by the MRI parameters on the level of the whole brain and in specific regions supports the in situ anti-inflammatory and neuroprotective consequences of GA treatment.
机译：炎症和变性以及灰质异常在多发性硬化症（MS）及其动物模型实验性自身免疫性脑脊髓炎（EAE）中的作用引起争议。我们使用先进的磁共振成像（MRI）参数分析了两种EAE模型的病理表现，即慢性少突胶质细胞糖蛋白（MOG）诱导与复发-释放蛋白脂蛋白（PLP）沿疾病进展。这项研究的重点是通过直方图分析对整个大脑进行总体评估，以及使用定量T2，磁化传递比（MTR）和扩散张量成像（DTI）通过基于体素的分析（VBA）检测特定的患病区域。 。两种模型中受EAE侵害的小鼠的大脑均显示出多个白质和灰质区域，而对于所有MRI参数而言，幼稚小鼠均具有显着变化。心室肿胀是PLP诱导模型的特征。主要在MOG诱导的EAE中观察到MTR值降低和表观扩散系数（ADC）升高，表明在慢性疾病中大分子损失和中枢神经系统结构受损。与未经治疗的EAE小鼠相比，用作预防或治疗药物的MS药物格拉替雷乙酸（GA）影响了所有MRI病理表现，导致T2值和心室容积降低，MTR升高和ADC降低。一致地，免疫组织化学分析表明GA处理后较少的组织学损伤和大量的增殖少突胶质祖细胞。 MRI参数在全脑水平和特定区域反映的较高的脑组织完整性支持了GA治疗的原位抗炎和神经保护作用。

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