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首页> 外文期刊>Burns: Including Thermal Injury >Safety and potential anticoagulant effects of nebulised heparin in burns patients with inhalational injury at Singapore General Hospital Burns Centre.
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Safety and potential anticoagulant effects of nebulised heparin in burns patients with inhalational injury at Singapore General Hospital Burns Centre.

机译：在新加坡综合医院烧伤中心，雾化肝素对吸入性烧伤烧伤患者的安全性和潜在的抗凝作用。

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BACKGROUND: Nebulised heparin, N-acetylcysteine (NAC) and salbutamol were shown to decrease reintubation rates, incidence of atelectasis and mortality in paediatric patients and reduce lung injury scores in adult burns patients with inhalational lung injury (ILI). Nebulised heparin, NAC and salbutamol treatment protocol was introduced in Singapore General Hospital (SGH) Burns Centre in 2006. However, safety data on the use of nebulised heparin and NAC for burns patients with ILI is not well established. In this study, we investigated the safety and potential anticoagulant effects of nebulised heparin in burns patients with ILI. METHODS: A retrospective study with historical control was conducted. The treatment group consisted of 52 mechanically ventilated adult patients, with a diagnosis of ILI as confirmed by bronchoscopy, admitted to burn intensive care unit (BICU) from the year 2006 to 2009. The group was treated with nebulised heparin, NAC and salbutamol. The control group consists of 11 mechanically ventilated BICU ILI patients treated from year 2001 to 2005 before protocol initiation. Blood coagulation indices (prothrombin time (PT), activated partial thromboplastin time (APTT) and platelet count) were monitored and bleeding incidences were assessed. FINDINGS: Blood coagulation indices did not suggest an increase risk of bleeding with nebulised heparin. The APTT, PT and platelet count followed a similar trend for both groups over 7 days. No clinically significant increase in bleeding risk was found to be associated with nebulised heparin. CONCLUSION: Nebulised heparin was not found to potentiate the risk of bleeding in burns patients with ILI.
机译：背景：显示雾化的肝素，N-乙酰半胱氨酸（NAC）和沙丁胺醇可降低小儿患者的再插管率，肺不张的发生率和死亡率，并降低吸入性肺损伤（ILI）的成年烧伤患者的肺损伤评分。新加坡总医院烧伤中心于2006年引入了雾化肝素，NAC和沙丁胺醇治疗方案。但是，关于雾化肝素和NAC在ILI烧伤患者中使用的安全性数据尚不明确。在这项研究中，我们调查了雾化肝素在ILI烧伤患者中的安全性和潜在的抗凝作用。方法：采用历史对照进行回顾性研究。治疗组由52例机械通气的成年患者组成，经支气管镜检查确诊为ILI，于2006年至2009年期间接受烧伤重症监护病房（BICU）。该组接受雾化肝素，NAC和沙丁胺醇治疗。对照组由11例机械通气的BICU ILI患者组成，他们从2001年到2005年在开始治疗方案之前接受了治疗。监测凝血指标（凝血酶原时间（PT），活化部分凝血活酶时间（APTT）和血小板计数），并评估出血发生率。结果：凝血指数并未提示雾化肝素会增加出血风险。两组在7天内的APTT，PT和血小板计数趋势相似。未发现与雾化肝素相关的出血风险的临床显着增加。结论：未发现雾化肝素可增强ILI烧伤患者出血的风险。

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