Does excitotoxic cell death of motor neurons in ALS arise from glutamate transporter and glutamate receptor abnormalities?

Rattray M; Bendotti C

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Does excitotoxic cell death of motor neurons in ALS arise from glutamate transporter and glutamate receptor abnormalities?

机译：ALS中运动神经元的兴奋性毒性细胞死亡是否由谷氨酸转运蛋白和谷氨酸受体异常引起？

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition resulting from progressive and selective loss of motor neurons, particularly those in the spinal cord. Despite much research, there is no single unifying consensus on the key events which underlie motor neuron cell death, and numerous mechanisms have been implicated that include enhanced oxidative stress and free radical production, abnormalities in axonal transport, protein aggregation, mitochondrial dysfunction and glutamate-mediated excitotoxicity. Excitotoxicity caused by glutamate, an endogenous neurotransmitter, is a long-standing concept and may be one of the major underlying causes of motor neuron loss in ALS. Briefly stated, glutamate excitotoxicity is a loss of control of normal glutamate transmission resulting in a calcium-mediated cell death through over activation of calcium-permeable glutamate receptors (Choi, 1988).

机译：肌萎缩性侧索硬化症（ALS）是一种致命的神经退行性疾病，是由运动神经元（尤其是脊髓中的神经元）进行性和选择性丧失所致。尽管进行了大量研究，但对于运动神经元细胞死亡的关键事件尚无统一的共识，并且涉及许多机制，包括增强的氧化应激和自由基产生，轴突运输异常，蛋白质聚集，线粒体功能障碍和谷氨酸-介导的兴奋性毒性。谷氨酸（一种内源性神经递质）引起的兴奋性毒性是一个长期存在的概念，并且可能是ALS中运动神经元丢失的主要潜在原因之一。简而言之，谷氨酸兴奋性毒性是对正常谷氨酸传递的控制的丧失，其通过钙可渗透性谷氨酸受体的过度活化而导致钙介导的细胞死亡（Choi，1988）。

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《Experimental Neurology》 |2006年第1期|共9页
作者
Rattray M; Bendotti C;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Amyotrophic Lateral Sclerosis; Motor Neurons; Receptors; Glutamate; 肌萎缩侧索硬化; 运动神经元; 受体; 谷氨酸;

机译：Amyotrophic Lateral Sclerosis;Motor Neurons;Receptors;Glutamate;肌萎缩侧索硬化;运动神经元;受体;谷氨酸;

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1. Does excitotoxic cell death of motor neurons in ALS arise from glutamate transporter and glutamate receptor abnormalities? [J] . Rattray M, Bendotti C Experimental Neurology . 2006,第1期

机译：ALS中运动神经元的兴奋性毒性细胞死亡是否由谷氨酸转运蛋白和谷氨酸受体异常引起？
2. Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity. [J] . Darman J, Backovic S, Dike S, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2004,第34期

机译：病毒引起的脊髓运动神经元死亡是非细胞自主的，涉及谷氨酸兴奋性毒性。
3. New insights into the mechanism of neurolathyrism: L-beta-ODAP triggers [Ca~(2+)]i accumulation and cell death in primary motor neurons through transient receptor potential channels and metabotropic glutamate receptors [J] . Kuniko Kusama-Eguchi, Takaaki Miyano, Makoto Yamamoto, Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research . 2014,第Null期

机译：关于神经性纤毛症机制的新见解：L-β-ODAP通过瞬时受体电位通道和代谢型谷氨酸受体触发原代运动神经元中的[Ca〜（2 +）] i积累和细胞死亡
4. Localizing GABA receptors and glutamate transporters using conjugated quantum dots in rat cerebellum slices [C] . Abdel I. El Abed, Anne Baudot, Mireille Chat, MRS Meeting . 2010

机译：使用缀合的量子点在大鼠小脑切片中定位GABA受体和谷氨酸转运蛋白
5. Extracellular glutamate regulates the abundance of glutamate receptors via xCT-like transporters. [D] . Augustin, Hrvoje. 2008

机译：细胞外谷氨酸通过类xCT转运蛋白调节谷氨酸受体的丰度。
6. Viral-Induced Spinal Motor Neuron Death Is Non-Cell-Autonomous and Involves Glutamate Excitotoxicity [O] . Jessica Darman, Stephanie Backovic, Sonny Dike, 2004

机译：病毒诱导的脊髓运动神经元死亡是非细胞自主的并涉及谷氨酸兴奋性毒性。
7. AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo [O] . Juan Carlos Corona, Ricardo Tapia 2004

机译：AMPA受体激活，但不是内源细胞外谷氨酸的积累，在大鼠脊髓中诱导瘫痪和运动神经元死亡

Does excitotoxic cell death of motor neurons in ALS arise from glutamate transporter and glutamate receptor abnormalities?

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