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首页> 外文期刊>Experimental dermatology >Role of CPI-17 in restoring skin homoeostasis in cutaneous field of cancerization: Effects of topical application of a film-forming medical device containing photolyase and UV filters
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Role of CPI-17 in restoring skin homoeostasis in cutaneous field of cancerization: Effects of topical application of a film-forming medical device containing photolyase and UV filters

机译：CPI-17在皮肤癌变皮肤领域中恢复皮肤稳态的作用：局部应用含有光裂解酶和紫外线过滤剂的成膜医疗器械的效果

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摘要

Cutaneous field of cancerization (CFC) is caused in part by the carcinogenic effect of the cyclobutane pyrimidine dimers CPD and 6-4 photoproducts (6-4PPs). Photoreactivation is carried out by photolyases which specifically recognize and repair both photoproducts. The study evaluates the molecular effects of topical application of a film-forming medical device containing photolyase and UV filters on the precancerous field in AK from seven patients. Skin improvement after treatment was confirmed in all patients by histopathological and molecular assessment. A gene set analysis showed that skin recovery was associated with biological processes involved in tissue homoeostasis and cell maintenance. The CFC response was associated with over-expression of the CPI-17 gene, and a dependence on the initial expression level was observed (P = 0.001). Low CPI-17 levels were directly associated with pro-inflammatory genes such as TNF (P = 0.012) and IL-1B (P = 0.07). Our results suggest a role for CPI-17 in restoring skin homoeostasis in CFC lesions.
机译：皮肤癌变（CFC）部分是由环丁烷嘧啶二聚体CPD和6-4光产物（6-4PPs）的致癌作用引起的。通过特异性识别和修复两种光产物的光解酶进行光活化。这项研究评估了局部应用含有光裂解酶和紫外线过滤剂的成膜医疗设备对7位患者AK癌前野的分子作用。通过组织病理学和分子评估，所有患者均证实治疗后皮肤改善。基因集分析表明，皮肤恢复与组织均位和细胞维持相关的生物学过程有关。 CFC反应与CPI-17基因的过表达相关，并且观察到对初始表达水平的依赖性（P = 0.001）。较低的CPI-17水平与促炎基因如TNF（P = 0.012）和IL-1B（P = 0.07）直接相关。我们的研究结果表明CPI-17在恢复CFC病变中皮肤稳态方面的作用。

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