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首页> 外文期刊>Experimental dermatology >Photodynamic therapy with topical methyl- and hexylaminolevulinate for prophylaxis and treatment of UV-induced SCC in hairless mice.
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Photodynamic therapy with topical methyl- and hexylaminolevulinate for prophylaxis and treatment of UV-induced SCC in hairless mice.

机译：局部和甲基氨基乙酰丙酸甲酯和乙酰氨基乙酰丙酸盐的光动力学疗法可预防和治疗无毛小鼠中的紫外线诱导的SCC。

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BACKGROUND: Hexyl aminolevulinate (HAL) is a long-chained 5-aminolevulinic acid-ester that has been proposed as a novel photosensitizing agent to methyl aminolevulinate (MAL) in topical photodynamic therapy (PDT). The more lipophilic HAL, may improve treatment outcome for non-melanoma skin cancer. OBJECTIVE: To compare the prophylactic and therapeutic effects of HAL- and MAL-PDT for ultraviolet-induced squamous cell carcinomas (SCCs) in hairless mice. METHODS: Mice (n = 249) were irradiated with solar UV-radiation (UVR) until SCC occurred. Before any skin changes developed, two prophylactic PDT treatments were given, using creams of HAL (2%, 6%, 20%) or MAL (20%) followed by illumination (632 nm, Aktilite, Photocure). Two therapeutic PDT-treatments were given by randomization to the first developed SCC of 1 mm. Primary end-points were time to first SCC of 1 mm and complete SCC clearance. Secondary end-points were time to SCC-recurrence, PpIX fluorescence and skin reactions to PDT. Results: The median time to first SCC was significantly longer for mice treated with prophylactic HAL-PDT (2%, 6% and 20% HAL, 264 days) and MAL-PDT (20% MAL, 269 days) than mice exposed to UVR (186 days) and UVR + placebo-PDT (199 days) (P < 0.0001). The therapeutic efficacy of HAL- and MAL-PDT showed cure rates of 23-61.5% (P = 0.11). Similar PpIX fluorescence intensity and severity of clinical reactions were seen for HAL- and MAL-groups, although mice developed more intense hyper-pigmentation when treated with 20% MAL-PDT compared with 2% HAL-PDT. CONCLUSIONS: PDT with HAL (2%, 6% and 20%) and MAL (20%) is equally effective to prevent and treat UV-induced SCC in hairless mice.
机译：背景：氨基乙酰丙酸己酯（HAL）是一种长链5-氨基乙酰丙酸酯，在局部光动力疗法（PDT）中已被提议作为一种新的对氨基乙酰丙酸甲酯（MAL）的光敏剂。亲脂性HAL越高，可能会改善非黑素瘤皮肤癌的治疗效果。目的：比较HAL和MAL-PDT对紫外线引起的无毛小鼠鳞状细胞癌的预防和治疗作用。方法：对249只小鼠进行太阳紫外线辐射（UVR）照射，直至出现SCC。在出现任何皮肤变化之前，先进行了两种预防性PDT治疗：先使用HAL（2％，6％，20％）或MAL（20％）的乳霜，再进行照明（632 nm，Aktilite，Photocure）。随机将两种治疗性PDT治疗给予第一个发展的1mm SCC。主要终点是第一次SCC到达1 mm的时间和SCC完全清除的时间。次要终点是SCC复发的时间，PpIX荧光和对PDT的皮肤反应。结果：与暴露于UVR的小鼠相比，接受预防性HAL-PDT（2％，6％和20％HAL，264天）和MAL-PDT（20％MAL，269天）治疗的小鼠到首次SCC的中位时间明显更长（186天）和UVR +安慰剂-PDT（199天）（P <0.0001）。 HAL和MAL-PDT的治疗效果显示治愈率为23-61.5％（P = 0.11）。 HAL组和MAL组的PpIX荧光强度和临床反应的严重程度相似，尽管与2％HAL-PDT相比，用20％MAL-PDT处理时小鼠会出现更强烈的色素沉着。结论：含HAL（2％，6％和20％）和MAL（20％）的PDT对预防和治疗紫外线引起的无毛小鼠SCC同样有效。

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