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Opine dehydrogenases in marine invertebrates

机译:海洋无脊椎动物中的高山脱氢酶

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It is well known today that opine production anaerobic pathways are analogs to the classical glycolytic pathway (lactate production pathway). These pathways, catalyzed by a group of enzymes called opine dehydrogenases (OpDHs), ensure continuous flux of glycolysis and a constant supply of ATP by maintaining the NADH/NAD+ ratio during exercise and hypoxia, thus regulating the cytosolic redox balance in glycolysis under anoxia. OpDHs are distributed in a wide range of marine invertebrate phyla, including sponges (Porifera). Phylogenetic analyses supported with enzymatic assays strongly indicate that sponge OpDHs constitute an enzyme class unrelated to other OpDHs. Therefore, OpDHs in marine invertebrates are divided into two groups, a mollusk/annelid type and a sponge type, which belongs to the OCD/mu-crystallin family.
机译:今天众所周知,鸦片生产厌氧途径类似于经典糖酵解途径(乳酸生产途径)。这些途径被称为阿片脱氢酶(OpDHs)的一组酶催化,通过在运动和缺氧期间维持NADH / NAD +的比例,确保糖酵解的连续通量和ATP的恒定供应,从而在缺氧条件下调节糖酵解中的胞质氧化还原平衡。 OpDHs分布在各种各样的海洋无脊椎动物门中,包括海绵(Porifera)。酶促测定支持的系统发育分析强烈表明,海绵OpDHs构成与其他OpDHs不相关的酶类别。因此,海洋无脊椎动物中的OpDHs分为两类,即软体动物/安息香型和海绵型,属于OCD / mu-crystallin家族。

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