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首页> 外文期刊>Experimental and clinical endocrinology and diabetes: Official journal, German Society of Endocrinology [and] German Diabetes Association >Curcumin Attenuates Urinary Excretion of Albumin in Type II Diabetic Patients with Enhancing Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) System and Repressing Inflammatory Signaling Efficacies
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Curcumin Attenuates Urinary Excretion of Albumin in Type II Diabetic Patients with Enhancing Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) System and Repressing Inflammatory Signaling Efficacies

机译：姜黄素可增强II型糖尿病患者的尿蛋白排泄，这些患者具有增强的核因子类红血球衍生的2-Like 2（Nrf2）系统并抑制炎症信号传导功效。

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摘要

Curcumin has a therapeutic potential in treating diabetic kidney disease (DKD) while potential mechanisms underlining this beneficial effect remain to be elucidated. In the present study, curcumin intervention was performed in patients with Type II diabetes mellitus (T2DM) by oral intake of curcumin at the dose of 500mg/day for a period of 15-30 days. Nephritic excretion of urinary micro-albumin (U-mAlb) and blood metabolic indexes were assessed before and after this intervention. In addition, the lipid oxidation index, malondialdehyde (MDA) in plasma and the status of anti-oxidative Nrf2 system in blood lymphocytes were measured. The effect of curcumin on inflammation was assessed by measuring plasma lipopolysaccharide (LPS) content and inflammatory signaling protein in blood lymphocytes. A self-comparison method was used for assessing statistical significances of these measurements. Here we show that curcumin intervention markedly attenuated U-mAlb excretion without affecting metabolic control of participated patients. In addition, curcumin reduced plasma MDA level with enhanced the Nrf2 system specifically regulated protein, NAD(P)H quinone oxidoreductase 1 (NQO-1) together with other anti-oxidative enzymes in patients' blood lymphocytes. Furthermore, we observed reduced plasma LPS content and increased IB, an inhibitory protein on inflammatory signaling in patient's lymphocytes after curcumin administration. Finally, several gut bacterials important for maintaining gut barrier integrity and function were upregulated by curcumin.
机译：姜黄素具有治疗糖尿病性肾病（DKD）的治疗潜力，而强调这种有益作用的潜在机制仍有待阐明。在本研究中，对II型糖尿病（T2DM）患者进行姜黄素干预，口服剂量为500mg /天的姜黄素，持续15-30天。在此干预之前和之后，评估尿微量白蛋白（U-mAlb）的肾排泄和血液代谢指标。此外，还测量了血浆中的脂质氧化指数，丙二醛（MDA）以及血液淋巴细胞中抗氧化Nrf2系统的状态。姜黄素对炎症的作用通过测量血浆淋巴细胞中的脂多糖（LPS）含量和炎症信号蛋白来评估。使用自我比较方法来评估这些测量值的统计显着性。在这里，我们显示姜黄素干预可显着减弱U-mAlb的排泄，而不会影响参与患者的代谢控制。此外，姜黄素通过增强Nrf2系统特异性调节的蛋白NAD（P）H醌氧化还原酶1（NQO-1）以及患者血液淋巴细胞中的其他抗氧化酶，降低了血浆MDA水平。此外，我们观察到姜黄素给药后血浆LPS含量降低，IB增加，IB是一种抑制患者淋巴细胞炎症信号的蛋白。最后，姜黄素上调了几种对维持肠道屏障完整性和功能很重要的肠道细菌。

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