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首页> 外文期刊>Experimental and clinical endocrinology and diabetes: Official journal, German Society of Endocrinology [and] German Diabetes Association >Growth hormone secretory response to intravenous galanin infusion in acromegalic patients.
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Growth hormone secretory response to intravenous galanin infusion in acromegalic patients.

机译：肢端肥大症患者对静脉注射甘丙肽输注的生长激素分泌反应。

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Galanin is a 29-amino acid neuropeptide which stimulates the secretion of growth hormone (GH) in normal men. Although the diagnosis of acromegaly involves demonstrating hypersecretion of GH and/or abnormalities in GH secretory dynamics, sometimes it is difficult to establish the activity of the disease. The aim of our study was to assess the response to galanin infusion in acromegalic patients (active and cured). We studied 19 subjects: 5 healthy volunteers (group I), 9 patients with active acromegaly (group II), and 5 with acromegaly cured after transsphenoidal surgery (group III). We performed a test of infusion with porcine galanin (8 microg/Kg/h) to study the secretory response of the GH. Galanin produced a marked increase in GH in the controls, group I (F9,36 = 5.34; p < 0.01) and in the cured patients, group III (F9,36 = 7.35; p < 0.01). On the other hand, galanin did not significantly modify the secretion of GH in the patients with active disease, group II. The areas under the curve (AUC) were higher in groups I and III compared to group II (p < 0.01). Nevertheless, there were no statistically significant differences in the AUC of groups I and III. Our results indicate that the differences in the GH response to galanin in patients with active and cured acromegaly could be of value in the study of the disease.
机译：甘丙肽是一种29个氨基酸的神经肽，可刺激正常男性的生长激素（GH）分泌。尽管肢端肥大症的诊断包括证实GH过度分泌和/或GH分泌动力学异常，但有时很难确定该疾病的活动。我们研究的目的是评估肢端肥大症患者（活动和治愈）对甘丙肽输注的反应。我们研究了19名受试者：5名健康志愿者（I组），9例活动性肢端肥大症患者（II组）和5例经蝶窦手术后治愈的肢端肥大症（III组）。我们进行了猪甘丙肽（8微克/千克/小时）输液测试，以研究生长激素的分泌反应。甘丙肽在对照组I组（F9,36 = 5.34; p <0.01）和治愈组III组（F9,36 = 7.35; p <0.01）中使GH显着增加。另一方面，II型活动性疾病患者的甘丙肽并未显着改变GH的分泌。与第二组相比，第一和第三组的曲线下面积（AUC）更高（p <0.01）。然而，第一和第三组的AUC在统计学上没有显着差异。我们的结果表明，活动性和治愈性肢端肥大症患者对甘丙肽的GH反应差异在该疾病的研究中可能具有价值。

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