Expression of leptin receptor mRNA and the long form splice variant in human anterior pituitary and pituitary adenoma.

Dieterich KD; Lehnert H

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Expression of leptin receptor mRNA and the long form splice variant in human anterior pituitary and pituitary adenoma.

机译：瘦素受体mRNA和长型剪接变体在人垂体前叶和垂体腺瘤中的表达。

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摘要

Expression of leptin receptor (OB-R) mRNA was detected in the human anterior pituitary as well as in ACTH-secreting and nonsecreting pituitary adenomas by RT-PCR with primers recognizing all receptor splice variants. Primers specific to the long splice variant of the leptin receptor (OB-Rb), containing the putative intracellular signalling domain, also revealed a strong expression in normal and adenomatous anterior pituitaries. These results indicate that the pituitary is a possible target tissue of leptin action and might be involved in leptin regulation of pituitary hormone secretion.

机译：通过RT-PCR，使用识别所有受体剪接变体的引物，在人垂体前叶以及分泌ACTH和不分泌垂体的腺瘤中检测到瘦素受体（OB-R）mRNA的表达。瘦素受体（OB-Rb）的长剪接变体特异的引物，包含推定的细胞内信号传导结构域，也显示出在正常和腺瘤性前垂体中的强表达。这些结果表明垂体是瘦素作用的可能靶组织，并且可能参与瘦素对垂体激素分泌的调节。

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《Experimental and clinical endocrinology and diabetes: Official journal, German Society of Endocrinology [and] German Diabetes Association》 |1998年第6期|共4页
作者
Dieterich KD; Lehnert H;
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正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
Adenoma; Carrier Proteins; Pituitary Gland; Anterior; Pituitary Neoplasms; 腺瘤; 载体蛋白质类; 垂体; 前叶; 垂体肿瘤; RNA剪接; RNA; 信使;

机译：Adenoma;Carrier Proteins;Pituitary Gland;Anterior;Pituitary Neoplasms;腺瘤;载体蛋白质类;垂体;前叶;垂体肿瘤;RNA剪接;RNA;信使;

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2. Expression of leptin receptor mRNA and the long form splice variant in human anterior pituitary and pituitary adenoma. [J] . Dieterich KD, Lehnert H Experimental and clinical endocrinology and diabetes: Official journal, German Society of Endocrinology [and] German Diabetes Association . 1998,第6期

机译：瘦素受体mRNA和长型剪接变体在人垂体前叶和垂体腺瘤中的表达。
3. Prognosis in human glioblastoma based on expression of ligand growth hormone-relasing hormone, pituitary-type growth hormone-releasing hormone receptor, its splicing variant receptors, EGF receptor and PTEN genes [J] . Geza Mezey, Andrea Treszl, Andrew V. Schally, Journal of Cancer Research and Clinical Oncology . 2014,第10期

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4. Altered expression of dopamine D2 receptor mRNA splice variants in brain and pituitary of spontaneously hypertensive rats. [J] . Autelitano DJ, van den Buuse M Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 1995,第1期

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7. The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues [O] . Alexandre Havt, Andrew V. Schally, Gabor Halmos, 2005

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机译：基于配体生长激素释放激素，垂体生长激素释放激素受体，其剪接变体受体，EGF受体和pTEN基因表达的人胶质母细胞瘤的预后

Expression of leptin receptor mRNA and the long form splice variant in human anterior pituitary and pituitary adenoma.

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